Inflammation

, Volume 9, Issue 1, pp 9–20 | Cite as

Inhibition of in vivo neutrophil accumulation by stress

Possible role of neutrophil adherence
  • Allen G. Harmsen
  • Thomas H. Turney
Original Articles

Abstract

Psychological stress results in neural and endocrine changes which can alter various aspects of the immune system. However, the effects of stress on inflammation has not received much attention despite the fact that stress hormones, such as the corticosteroids, are known to reduce inflammation. The present study extends a previous finding that stress itself can reduce inflammation. In the first experiment, zymosan was injected into an air pouch on the dorsum of F344 rats. Half of these rats then received three hours of inescapable, intermittent, electric foot shock as a Stressor, The other half of the injected rats served as nonstressed controls. A third group were given air pouches but no zymosan. Fewer neutrophils accumulated at the inflammatory site of stressed rats as compared to nonstressed control rats. However, phagocytosis of zymosan by air pouch neutrophiis was higher in stressed rats. Peripheral perfusion was not altered significantly by shock, but vascular permeability was reduced in stressed rats. The effects of stress on peripheral blood leukocytes of rats not injected with zymosan was investigated. It was found that while peripheral blood monocytes and lymphocyte numbers were decreased by stress, neutrophils were not decreased. Increased neutrophil adherence was found in stressed rats. Additionally, in the presence of endotoxin, neutrophils from stressed rats did not increase their adherence as much as those of control rats. The increased adhesiveness of neutrophils in stressed animals may account for the diminished inflammatory response in the shocked rats.

Keywords

Corticosteroid Vascular Permeability Psychological Stress Endocrine Change Blood Monocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Voors, A. W., G. T. Stewart, R. R. Gutekunst, C. F. Moldow, andC. D. Jenkins. 1968. Respiratory infections in Marine recruits: Influence of personal characteristics.Am. Rev. Respir. Dis. 98:801–809.Google Scholar
  2. 2.
    Jacobs, M. A., A. Z. Spilken, M. M. Norman, andL. S. Anderson. 1970. Life stress and respiratory illness.Psychosom. Med. 32:233–242.Google Scholar
  3. 3.
    Rogers, M. P., D. Dubey, andP. Reich. 1979. The influence of psyche and the brain on immunity and disease susceptibility: A critical review.Psychosom. Med. 41:147–164.Google Scholar
  4. 4.
    Zeitlsn, D. J. 1977. Psychological issues in the management of rheumatoid arthritis.Psychosomatics 18:7–14.Google Scholar
  5. 5.
    Barchas, J. D., I. N. Mefford, K. Roth, J. Madden IV, andP. R. Barchas. 1981. Neuroregulators and Stress.Naval Res. Rev. 23:2–12.Google Scholar
  6. 6.
    Borysenko, J. Z. 1982. Higher cortical function and neoplasia: Psychoneuroimmunology.In Biological Mediators of Behavior and Disease: Neoplasia. S. M Levy, editor Elsevier Biomdeical, New York, 29–54.Google Scholar
  7. 7.
    Ahlqvist, J. 1981. Hormonal influences on immunologie and related phenomena.In Psychoneuroimmunology. R. Ader, editor. Academic Press, New York, 355–403.Google Scholar
  8. 8.
    Mathews, P. M., C. J. Froelich, W. L. Sibbitt, andA. D. Bankhurst. 1983. Enhancement of natural cytotoxicity byβ-endorphin.J. Immunol. 130:1658–1662.Google Scholar
  9. 9.
    Stevenson, H. C., andA. S. Fauci. 1981. The effect of glucocortieoids and other hormones on inflammatory and immune responses.In Cellular Functions in Immunity and Inflammation. J. J. Oppenheim, D. L. Rosenstreich, and M. Potter, editor. Elsevier/North-Holland, New York, 431–451.Google Scholar
  10. 10.
    Bassett, J. R., andN. N. Tait. 1981. The effect of stress on the migration of leukocytes into the peritoneal cavity of rats following injection of an inflammatory agent.Aust. J. Exp. Biol. Med. Sci. 59:651–656.Google Scholar
  11. 11.
    Takahashi, L. K., andR. J. Blanchard. 1978. Shock and defensive fighting in the rat.Bull. Psychon. Soc. 12:211–213.Google Scholar
  12. 12.
    Henry, J. P., andP. M. Stephens. 1977. Stress, Health, and the Social Environment: A Sociobiologic Approach to Medicine. Springer-Verlag, New York.Google Scholar
  13. 13.
    Tsurufuji, S., S. Yoshino, andK. Ohuchi. 1982. Induction of an allergic air-pouch inflammation in rats.Im. Arch, Allergy Appl. Immunol. 69:189–198.Google Scholar
  14. 14.
    Dahinden, C., C. Galanos, andJ. Fehr. 1983. Granulocyte activation by endotoxin. I. Correlation between adherence and other granulocyte functions, and the role of endotoxin structure on biologic activity.J. Immunol. 130:857–862.Google Scholar
  15. 15.
    Rosenbaum, J. T., K. T. Hartiala, R. O. Webster, E. L. Howes. andI. M. Goldstein. 1983. Antiinflammatory effects of endotoxin: Inhibition of rabbit polymorphonuclear leukocyte responses to complement (C5)-derived peptides in vivo and in vitro.Am J. Pathol. 133:291–299.Google Scholar
  16. 16.
    Bjork, J., P. Hedqvist, andK. E. Arpors. 1982. Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes.Inflammation 6:189–200.Google Scholar
  17. 17.
    Schmeling, D. J., C. G. Gemmell, P. R. Craddock, P. G. Quie, andP. K. Peterson. 1981. Effect of staphylococcal α-toxin on neutrophit migration and adhesiveness.Inflammation 5:313–322.Google Scholar
  18. 18.
    Bowman, C. M., R. N. Harada, andJ. E. Repine. 1983. Hyperoxia stimulates alveolar macrophages to produce and release a factor which increases neutrophil adherence.Inflammation 7:331–338.Google Scholar
  19. 19.
    Dahinden, C., andJ. Fehr. 1983. Granulocyte activation by endotoxin. II. Role of granulocyte adherence, aggregation, and effect of cytochalasin B, and comparison with formylated chemotactic peptide-induced stimulation.J. Immunol. 130:863–868.Google Scholar
  20. 20.
    Cohn, Z. A., andSt. I. Morse. 1960. Functional and metabolic properties of polymorphonuclear leukocytes. II. The influence of a lipopoly saccharide endotoxin.J. Exp. Med. 3:689–693.Google Scholar
  21. 21.
    Van Epps, D. E., L. Saland, C. Taylor, andR. C. Williams, Jr. 1983. In vitro and in vivo effects of beta-endorphin and met-enkephalin on leukocyte locomotion.In Immunology of Nervous System Infections, Progress in Brain Research, Vol. 59. P. O. Behar, V. Meulen, and F. Clifford Rose, editor. Eisevier, N.Y.Google Scholar
  22. 22.
    Shavit, Y., J. W. Lewis, G. W. Terman, R. P. Gale, andJ. C. Liebeskind. 1984. Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity.Science 223:188–190.Google Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Allen G. Harmsen
    • 1
  • Thomas H. Turney
    • 2
  1. 1.Department of BiologyNew Mexico TechSocorro
  2. 2.Department of PsychologyNew Mexico TechSocorro

Personalised recommendations