Journal of Clinical Immunology

, Volume 6, Issue 5, pp 402–410

Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid

  • Donald G. Payan
  • Michael Y. S. Wong
  • Tania Chernov-Rogan
  • Frank H. Valone
  • Walter C. Pickett
  • Vincent A. Blake
  • Warren M. Gold
  • Edward J. Goetzl
Original Articles

DOI: 10.1007/BF00915380

Cite this article as:
Payan, D.G., Wong, M.Y.S., Chernov-Rogan, T. et al. J Clin Immunol (1986) 6: 402. doi:10.1007/BF00915380

Abstract

Two groups of six adults with persistent asthma, who were identical clinically, received 0.1 or 4 g of purified eicosapentaenoic acid ethyl ester (EPA) daily for 8 weeks. Both doses increased significantly the generation of leukotriene B5 (LTB5) from EPA by polymorphonuclear (PMN) and mononuclear leukocytes, while only the high dose decreased leukocyte arachidonic acid (AA) and the generation of LTB4 and prostaglandin E2 from AA. Only the high dose led to inhibition of PMN leukocyte chemotaxis to multiple stimuli by a mean of 57–70% (P<0.01), without altering monocyte chemotaxis, the production of plateletactivating factor by mononuclear leukocytes, or the IgE-dependent release of histamine from basophils. Both doses of EPA increased the responses of T lymphocytes to phytohemagglutinin by a mean of 73% or more (P<0.01) without modifying the numbers of helper and suppressor T lymphocytes. EPA affects the functions of several types of leukocytes critical to inflammation and immunity.

Key words

Leukocytes arachidonic acid leukotrienes eicosapentaenoic acid asthma 

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Donald G. Payan
    • 1
    • 2
  • Michael Y. S. Wong
    • 2
  • Tania Chernov-Rogan
    • 1
    • 2
  • Frank H. Valone
    • 2
  • Walter C. Pickett
    • 4
  • Vincent A. Blake
    • 3
  • Warren M. Gold
    • 2
  • Edward J. Goetzl
    • 1
    • 2
  1. 1.Howard Hughes Medical InstituteUniversity of California Medical CenterSan Francisco
  2. 2.Department of MedicineUniversity of California Medical CenterSan Francisco
  3. 3.School of PharmacyUniversity of California Medical CenterSan Francisco
  4. 4.Lederle LaboratoriesPearl River

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