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Acquired hypogammaglobulinemia following infectious mononucleosis

Abstract

The case of a 17-year-old male who developed hypogammaglobulinemia following infectious mononucleosis is presented. The family history revealed that a male sibling had died some years earlier with encephalitis also following infectious mononucleosis. Laboratory investigations revealed adequate numbers of T and B cells and normal proportions of helper and suppressor T lymphocytes but poorin vitro responses to mitogens and an absence of hypersensitivity to skin test antigens. Serial serological examinations for Epstein-Barr virus antibodies indicated a primary immune response to this virus in a hypogammaglobulinemic individual. The patient probably represents a case of the X-linked lymphoproliferative syndrome. The unique feature of the present case is the demonstration of Epstein-Barr virus-specific T-cell memory. The significance of this finding and the variable expression of this syndrome in two members of the same family are discussed.

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Correspondence to John F. Greally.

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Greally, J.F., Lawlor, E., Lyons, J. et al. Acquired hypogammaglobulinemia following infectious mononucleosis. J Clin Immunol 3, 207–211 (1983). https://doi.org/10.1007/BF00915344

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Key words

  • Hypogammaglobulinemia
  • Epstein-Barr virus
  • X-linked lymphoproliferative syndrome