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Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium

Time course and dose-response relationships

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Abstract

The hamster cheek pouch microcirculation was used to investigate the effects of platelet-activating factor (PAF) on leukocyte adhesion to microvascular walls by means of intravital microscopy. PAF was applied topically at concentrations ranging from 10−11 to 10−5 M. An inverse relationship between PAF concentration and number of adhering white cells per 100-Μm length was found in venules ranging in diameter from 10 to 60 Μm (grouped into 10-Μm intervals). Importantly, the PAF-induced adhesion of leukocytes lasted for the 3-h experimental period. We postulate that induction of leukocyte adhesion to venular endothelium is an important role of PAF in inflammatory processes.

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Dillon, P.K., Fitzpatrick, M.F., Ritter, A.B. et al. Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Inflammation 12, 563–573 (1988). https://doi.org/10.1007/BF00914318

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Keywords

  • Public Health
  • Internal Medicine
  • Inflammatory Process
  • Inverse Relationship
  • Experimental Period