Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Sila-Analoga des Chlorphenoxamins und des Clofenetamins

Sila-Pharmaka, 2. Mitt.

Sila-analogues of chlorphenocamine and clofenetamine

Sila-pharmaca, 2

  • 21 Accesses

  • 7 Citations

Abstract

Sila-analoguesA 2 andB 2 of two drugs from the benzhydryl ether class, chlorphenoxamine and clofenetamine, were synthesized for the first time by the steps shown in scheme 1. They and their precursors I–VI were characterized by their physical (Table 1) and chemical properties and their structures confirmed by n.m.r., mass and infrared spectrocopy (Tables 2–5). Their physiological effects were investigated and compared with those of the carbon analogues (Chapter 5).

This is a preview of subscription content, log in to check access.

Literatur

  1. 3

    G. Ehrhart undH. Ruschig, Arzneimittel, Band 1, S. 298, 307. Weinheim: Verlag Chemie. 1972.—E. Mutschler, Arzneimittelwirkungen, S. 234 bis 238. Stuttgart: Wissenschaftl. Verlagsges. mbH. 1973.

  2. 4

    H. Arnold undE. Kühas, Asta-Werke, DBP. 952 715 (1956); Chem. Abstr.53, 8074h (1959); dtsch. Pat. 1 009 193; Chem. Abstr.54, 434g (1960).

  3. 5

    Z. V. Belyakova undS. A. Golubtsov, Zh. Obshch. Khim.31, 3178 (1961); Chem. Abstr.56, 15 532 (1962).

  4. 6

    Z. V. Belyakova, M. G. Pomerantseva undS. A. Golubtsov, Zh. Obshch. Khim.35, 1048 (1965); Chem. Abstr.63, 9978 (1965).

  5. 7

    E. P. Mikheev undB. A. Charskaya, Plast. Mass.1966, 32; Chem. Abstr.65, 20 157 (1966).

  6. 8

    G. S. Popeleva, V. I. Savushkina, K. A. Andrianov undS. A. Golubtsov, Zh. Obshch. Khim.32, 557 (1962); Chem. Abstr.58, 6853 (1963).

  7. 9

    F. Meyer undH.-U. Rossée, unveröffentlicht;H.-U. Rossée, Dissertation Technische Universität Braunschweig 1974.

  8. 10

    H. Arnold, N. Brock, E. Kühas undD. Lorenz, Arzneimittel-Forsch.4, 189 (1954).

Download references

Author information

Correspondence to Ulrich Wannagat.

Additional information

1. Mitt.:R. Tacke undU. Wannagat, Mh. Chem.106, 1005 (1975).

Mit Auszügen aus der DissertationR. Tacke, Techn. Univ. Braunschweig 1974.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tacke, R., Wannagat, U. Sila-Analoga des Chlorphenoxamins und des Clofenetamins. Monatshefte für Chemie 107, 111–123 (1976). https://doi.org/10.1007/BF00909088

Download citation