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Some α-amino acids containing trifluoromethyl groups

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Ethanolamine was added to β, β-ditrifluoromethylacrylic ester and hexafluorovaline ester was hydroxyethylated. Both reactions yielded the ester of N-(β-hydroxyethyl)-hexafluorovaline, which could be used as the starting material for the synthesis of physiologically active substances.

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Literature cited

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    H. Walborsky, M. Baum, D. Loncrini, J. Amer. Chem. Soc.77, 3637 (1955).

  2. 2.

    I. L. Knunyants and Yu. A. Cheburkov, Izvest. Akad. Nauk SSSR, Otdel. Khim. Nauk. (1960) (In the press).

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Knunyants, I.L., Cheburkov, Y.A. Some α-amino acids containing trifluoromethyl groups. Russ Chem Bull 9, 1411–1412 (1960). https://doi.org/10.1007/BF00907682

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  • Ester
  • Active Substance
  • Ethanolamine
  • Trifluoromethyl
  • Hydroxyethylated