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Eine neue Cyclolestersynthese zum Aufbau von Ergot-Peptidalkaloiden 82. Mitt. über Mutterkornalkaloide

A new synthesis for cyclol esters as starting materials for ergot alkaloids of the peptide type

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Abstract

Starting from acylated dipeptides of the general formula G the so-called cyclol esters D are stereospecifically formed in good yields after treatment with a base in polar aprotic solvents. These compounds D are key intermediates for the synthesis of ergot alkaloids of the peptide type. Extension of the scope of this reaction i.e. cyclisation of corresponding acylated dipeptides, the terminal proline being replaced by another amino acid bearing a primary nitrogen atom, could not be verified.

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Author information

Correspondence to Dr. Peter Stütz.

Additional information

Herrn Prof. Dr.O. Hromatka zum 70. Geburtstag gewidmet.

81. Mitt.:W. Acklin, T. Fehr undP. A. Stadler, Helv. Chim. Acta58, 2492 (1975).

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Stütz, P., Stadler, P.A. Eine neue Cyclolestersynthese zum Aufbau von Ergot-Peptidalkaloiden 82. Mitt. über Mutterkornalkaloide. Monatshefte für Chemie 107, 763–775 (1976). https://doi.org/10.1007/BF00906783

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