Cardiovascular Drugs and Therapy

, Volume 7, Issue 6, pp 929–934

Exercise tolerance in angina is improved by mivazerol—An alpha2-adrenoceptor agonist

  • Robert Anthony Wright
  • Philippe Decroly
  • Tatiana Kharkevitch
  • Michael F. Oliver
Angina

Summary

In a double-blind, placebo-controlled, randomized trial of treadmill exercise tolerance in six patients with chronic stable angina, intravenous mivazerol 1 µg, 2 µg, and 3 µg/kg increased in the time to onset of angina by 39%, 48%, and 76%; the time to 1-mm ST depression by 36%, 76%, and 104%; and total exercise duration by 15%, 23%, and 30%, respectively. In a subsequent double-blind, placebo-controlled, randomized trial involving a further 12 patients, a single oral dose of mivazerol of 800 µg, 1200 µg, and 1600 µg increased the time to onset of angina by 4%, 11%, and 30%; the time to 1-mm ST depression by 33%, 43%, and 53%; and the total exercise duration by 10%, 18%, and 23%, respectively. Mivazerol is an imidazole derivative with agonist properties at the alpha2-adrenoceptor and appears to be an effective antianginal. Mivazerol may improve exercise performance by attenuating the effects of exercise-induced sympathetic nervous system activity on the ischemic myocardium.

Key Words

mivazerol alpha2 adrenoceptor angina exercise tolerance 

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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Robert Anthony Wright
    • 1
  • Philippe Decroly
    • 2
  • Tatiana Kharkevitch
    • 2
  • Michael F. Oliver
    • 1
  1. 1.Cardiovascular Research UnitUniversity of EdinburghScotland
  2. 2.UCB SA, Pharma SectorBrusselsBelgium
  3. 3.Department of CardiologyRoyal InfirmaryEdinburghScotland

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