European Journal of Clinical Pharmacology

, Volume 18, Issue 6, pp 497–500

Randomized double-blind study of prophylactic methenamine hippurate treatment of patients with indwelling catheters

  • A. Norberg
  • B. Norberg
  • U. Parkhede
  • H. Gippert
  • K. Lundbeck
Original

DOI: 10.1007/BF00874662

Cite this article as:
Norberg, A., Norberg, B., Parkhede, U. et al. Eur J Clin Pharmacol (1980) 18: 497. doi:10.1007/BF00874662

Summary

Catheterized patients with heavy bacteriuria and short catheter life received a shortcourse of antimicrobial therapy and then were allocated at random to double-blind treatment for 5 months with methenamine hippurate (MH), 1 g three times daily, or placebo 1 g 3 times daily. MH treatment reduced the number of catheter blockages and instances of spontaneous removal of the catheter, and doubled catheter life (p<0.001). It is suggested that the doubled catheter life was due to the reduced bacteriuria and lowering of urinary pH.

Key words

methenamine hippurate urinary tract infection geriatric patients indwelling catheter catheter life 

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • A. Norberg
    • 1
  • B. Norberg
    • 1
    • 3
  • U. Parkhede
    • 2
  • H. Gippert
    • 1
  • K. Lundbeck
    • 1
  1. 1.Department of Internal Medicine, Saint Lars HospitalUniversity of LundLundSweden
  2. 2.3M Riker LaboratoriesSkärholmenSweden
  3. 3.Department of Internal MedicineUniversity Hospital of UmeåUmeåSweden

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