Randomized double-blind study of prophylactic methenamine hippurate treatment of patients with indwelling catheters
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- Norberg, A., Norberg, B., Parkhede, U. et al. Eur J Clin Pharmacol (1980) 18: 497. doi:10.1007/BF00874662
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Catheterized patients with heavy bacteriuria and short catheter life received a shortcourse of antimicrobial therapy and then were allocated at random to double-blind treatment for 5 months with methenamine hippurate (MH), 1 g three times daily, or placebo 1 g 3 times daily. MH treatment reduced the number of catheter blockages and instances of spontaneous removal of the catheter, and doubled catheter life (p<0.001). It is suggested that the doubled catheter life was due to the reduced bacteriuria and lowering of urinary pH.