Antonie van Leeuwenhoek

, Volume 65, Issue 3, pp 179–182 | Cite as

Regulatory circuits of theamdS gene ofAspergillus nidulans

  • Michael J. Hynes


TheamdS gene codes for an acetamidase enzyme that hydrolyses acetamide to acetate and ammonium thus providingA. nidulans with a source of carbon and nitrogen. The exceptionally favourable genetics of this system combined with molecular analysis have enabled many regulatory circuits affectingamdS to be identified genetically. Characterization of the regulatory genes and the definition of the cis-acting sites involved have been done using bothin vivo andin vitro mutagenesis. Recent results on the analysis of the system are presented.

Key words

Aspergillus fungus catabolism activation repression nitrogen carbon zinc fingers 


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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Michael J. Hynes
    • 1
  1. 1.Department of GeneticsUniversity of MelbourneParkvilleAustralia

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