Antonie van Leeuwenhoek

, Volume 66, Issue 1–3, pp 223–237

Glycine metabolism in anaerobes

  • Jan R. Andreesen
Research Articles


Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins PB, reduction of sarcosine or betaine to acetyl phosphate involves inEubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein Pc interacting with the intermediarily formed Secarboxymethylselenoether bound to protein PA.

Key words

Stickland reaction Clostridum Eubacterium Peptostreptococcus glycine sarcosine creatine betaine purines theronine proline glycine cleavage system glycine reductase selenoprotein thioredoxin system 


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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Jan R. Andreesen
    • 1
  1. 1.Institute of MicrobiologyUniversity of HalleHalleGermany

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