Antonie van Leeuwenhoek

, Volume 66, Issue 1–3, pp 223–237 | Cite as

Glycine metabolism in anaerobes

  • Jan R. Andreesen
Research Articles


Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins P B , reduction of sarcosine or betaine to acetyl phosphate involves inEubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein P c interacting with the intermediarily formed Secarboxymethylselenoether bound to protein P A .

Key words

Stickland reaction Clostridum Eubacterium Peptostreptococcus glycine sarcosine creatine betaine purines theronine proline glycine cleavage system glycine reductase selenoprotein thioredoxin system 


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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Jan R. Andreesen
    • 1
  1. 1.Institute of MicrobiologyUniversity of HalleHalleGermany

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