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Pharmacokinetics of single and multiple doses of flusoxolol (Ro 31-1411) in healthy subjects


Flusoxolol (Ro 31-1411) is the pharmacologically active optical isomer of Ro 31-1118, a potent cardioselective β-adrenoceptor antagonist with partial agonist activity. It was given to 6 healthy volunteers in a single dose, 40 mg, and then in multiple doses, 40 mg daily for 8 days.

Plasma concentration data were best described by a linear two-compartment pharmacokinetic model with first order absorption, and the results confirmed linear kinetics.

Pharmacokinetic data for flusoxolol were comparable to those for the racemate Ro 31-1118.

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Gillies, H.C., Rogers, H.J., Francis, R.J. et al. Pharmacokinetics of single and multiple doses of flusoxolol (Ro 31-1411) in healthy subjects. Eur J Clin Pharmacol 31, 113–115 (1986).

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Key words

  • flusoxolol
  • multiple-dose
  • pharmacokinetics
  • Ro 31-1118
  • optical isomer