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European Journal of Clinical Pharmacology

, Volume 31, Issue 1, pp 63–68 | Cite as

Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension

  • C. K. van Kalken
  • J. van der Meulen
  • P. L. Oe
  • R. Vriesendorp
  • A. J. M. Donker
Originals

Summary

The kinetics and short-term (10 weeks) effects of trimazosin, an alpha1-adrenoreceptor antagonist, on renal function and blood pressure in patients with moderate chronic renal insufficiency and hypertension, have been studied for the first time. Eight patients in whom the blood pressure was not normalized with a diuretic alone underwent pharmacokinetic studies and assessment of the renal function during a 10-week period of trimazosin therapy. Trimazosin significantly lowered blood pressure (recumbent and upright) without significantly altering renal function. Renal vascular resistance was decreased by 14%. Fractional sodium excretion, proteinuria and laboratory serum tests remained unchanged. Neither body weight nor pulse rate were affected. Moderate renal insufficiency did not modify the pharmacokinetics of the drug. Thus, trimazosin, as second-step antihypertensive agent, appeared to be safe and effective in patients with moderate renal insufficiency and hypertension, without exerting favourable or adverse renal effects during short-term therapy.

Key words

trimazosin proteinuria chronic renal insufficiency hypertension glomerular filtration rate renal vascular resistance pharmacokinetics 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • C. K. van Kalken
    • 1
  • J. van der Meulen
    • 1
  • P. L. Oe
    • 1
  • R. Vriesendorp
    • 1
  • A. J. M. Donker
    • 1
  1. 1.Department of MedicineFree University HospitalAmsterdamThe Netherlands

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