Springer Seminars in Immunopathology

, Volume 19, Issue 2, pp 245–256 | Cite as

DNA vaccines: safety and efficacy issues

  • Dennis M. Klinman
  • Mitsuhiro Takeno
  • Motohide Ichino
  • Mili Gu
  • Galina Yamshchikov
  • Gil Mor
  • Jacqueline Conover


DNA technology has been harnessed to produce a variety of plasmid-based vaccines designed to prevent viral, bacterial and parasitic infections. The rapid adoption and implementation of this novel vaccine strategy carries with it important safety and efficacy concerns. This review will focus on whether DNA vaccines (1) are likely to induce systemic or organ-specific autoimmune disease, (2) have the potential to induce tolerance rather than immunity, and (3) are as effective in individuals with depressed immune function as they are in healthy adults.


Internal Medicine Autoimmune Disease Immune Function Healthy Adult Harness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Dennis M. Klinman
    • 1
  • Mitsuhiro Takeno
    • 1
  • Motohide Ichino
    • 1
  • Mili Gu
    • 1
  • Galina Yamshchikov
    • 1
  • Gil Mor
    • 1
  • Jacqueline Conover
    • 1
  1. 1.Section of Retroviral Immunology, Division of Viral ProductsCenter for Biologics Research and Evaluation, Food and Drug AdministrationBethesdaUSA

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