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Non-linearity of insulin kinetics


  1. 1.

    Sönksen PH, Tompkins CV, Srivastava MC, Nabarro JDN (1973) A comparative study in the metabolism of human insulin and porcine proinsulin in man. Clin Sci Mol Med 45: 633–654

  2. 2.

    Sherwin RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist JE, Berman M, Andres R (1974) A model of the kinetics of insulin in man. J Clin Invest 53:1481–1492

  3. 3.

    Fugleberg S, Kølendorf K, Thorsteinsson B, Bliddal H, Lund B, Bojsen F (1982) The relationship between plasma concentration and plasma disappearance rate of immunoreactive insulin normal subjects. Diabetologia 22: 437–440

  4. 4.

    Jones RH, Sönksen PH, Boroujerdi MA, Carson ER (1984) Number and affinity of insulin receptors in intact human subjects. Diabetologia 27:207–211

  5. 5.

    Thorsteinsson B, Fugleberg S, Feldt-Rasmussen B, Binder C (1985) Kinetic models for plasma disappearance of insulin in normal subjects. Acta Pharmacol Toxicol 57: 309–316

  6. 6.

    Cobelli C, Mari A, Ferrannini E (1986) On linearity of insulin kinetics. Am J Physiol (Endocrinol Metab) E247–E248

  7. 7.

    DeFeo P, Perriello G, Venture MM, Calcinaro F, Basta G, Lolli G, Cruciani C, Dell'Olio A, Santeusanio F, Brunetti P, Bolli GB (1986) Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon. Diabetologia 29: 475–480

  8. 8.

    Frost DB, Srivastava MC, Jones RH, Nabarro JDN, Sönksen PH (1973) The kinetics of insulin metabolism in diabetes mellitus. Postgrad Med J 49: 949–954

  9. 9.

    Carson ER, Cobelli C, Finkelstein L (1983) The mathematical modeling of metabolic and endocrine systems. Wiley, New York, pp: 1–394

  10. 10.

    Thorsteinsson B, Fugleberg S, Feldt-Rasmussen B, Ellemann K, Andersen OO, Binder C (1986) Kinetic models for insulin disappearance from plasma in type I diabetic patients. Acta Pharmacol Toxicol (in press)

  11. 11.

    Franckson JRM, Ooms HA (1973) The catabolism of insulin in the dog: evidence for the existence of two catabolic pathways. Postgrad Med J 49: 931–939

  12. 12.

    Polonsky K, Jaspan J, Emmanouel D, Holmes K, Moossa AR (1983) Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism. Acta Endocrinol 102: 420–427

  13. 13.

    Morishima T, Bradshaw C, Radziuk J (1985) Measurment using tracers of steady-state turnover and metabolic clearance of insulin in dogs. Am J Physiol (Endocrinol Metab) E203–E208

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Thorsteinsson, B. Non-linearity of insulin kinetics. Diabetologia 29, 898 (1986).

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  • Public Health
  • Internal Medicine
  • Human Physiology
  • Metabolic Disease
  • Insulin Kinetic