Pediatric Nephrology

, Volume 6, Issue 4, pp 383–393

Aluminum toxicity in childhood

  • Aileen Sedman
Invited Review

DOI: 10.1007/BF00869743

Cite this article as:
Sedman, A. Pediatr Nephrol (1992) 6: 383. doi:10.1007/BF00869743


Aluminum intoxication is an iatrogenic disease caused by the use of aluminum compounds for phosphate binding and by the contamination of parenteral fluids. Although organ aluminum deposition was noted as early as 1880 and toxicity was documented in the 1960s, the inability to accurately measure serum and tissue aluminum prevented delineation of its toxic effects until the 1970s. Aluminum toxicity has now been conclusively shown to cause encephalopathy, metabolic bone disease, and microcytic anemia.

Key words

Aluminum Childhood renal failure Encephalopathy Osteomalacia Microcytic anemia Aluminum-containing antacids 

Copyright information

© IPNA 1992

Authors and Affiliations

  • Aileen Sedman
    • 1
  1. 1.Department of PediatricsUniversity of Michigan Medical CenterMIAnn ArborUSA

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