Pediatric Nephrology

, Volume 6, Issue 4, pp 323–327 | Cite as

A reappraisal of the measurement of glomerular filtration rate in pre-term infants

  • Barry H. Wilkins
Original Article
Received:
Revised:
Accepted:

Abstract

Thirty-seven single-injection polyfructosan-S (PF-S, Inutest®) and 98 continuous-infusion PF-S/creatinine clearance studies were performed in 39 sick very low birth weight infants. The single-injection clearance method for measuring glomerular filtration rate has been shown to be a reliable technique if sampling is continued for 8 h or more and the PF-S (Inutest®) assay is sensitive, accurate and precise. The continuous-infusion clearance method is also valid if the infusion is continued for more than 24 h and preceded by a loading dose in the form of a double-rate infusion for 8 h. Creatinine clearance is usually less than PF-S clearance, the mean ratio being 0.91, suggesting that there is some creatinine reabsorption in the renal tubule in sick very low birth weight infants.

Key words

Glomerular filtration rate Pre-term infant Newborn Inulin Polyfructosan-S Creatinine Clearance 
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Copyright information

© IPNA 1992

Authors and Affiliations

  • Barry H. Wilkins
    • 1
    • 2
  1. 1.Department of Child HealthBristol UniversityBristolUK
  2. 2.Neonatal Intensive Care UnitSouthmead HospitalBristolUK

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