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Diabetologia

, Volume 29, Issue 9, pp 640–643 | Cite as

Prevalence of microalbuminuria in children with Type 1 (insulin-dependent) diabetes mellitus

  • E. R. Mathiesen
  • N. Saurbrey
  • E. Hommel
  • H. -H. Parving
Originals

Summary

The prevalence of microalbuminuria was determined in children aged 7 to 18 years with Type 1 (insulin-dependent) diabetes of more than 2 years' duration. All patients (n =102) attending 2 diabetes clinics were asked to collect 2 overnight timed urine samples for albumin analysis by radioimmunoassay. Complete urine collection was obtained in 97 patients (95%). Overnight urinary albumin excretion rates were also measured in 36 healthy children matched for age and sex. Nineteen of the 97 patients (20%) had microalbuminuria, i. e. overnight urinary albumin excretion rates above the upper normal level (14 μg/min) in both urine collections. Microalbuminuria was only demonstrated in patients aged ≥ 15 years, prevalence 37% (19/52 patients). Arterial blood pressure was elevated, mean 122/84±11/9mmHg, in the microalbuminuric group (19 patients) compared to the age-matched normoalbuminuric diabetic group (33 patients), mean 117/74±10/10 mm Hg,p < 0.001. The prevalence of simplex retinopathy was identical in these two groups, i. e. 25%. Glycosylated haemoglobin was slightly higher in the microalbuminuric patients,p < 0.10. Our cross-sectional study reveals a high prevalence (37%) of persistent microalbuminuria, a stage highly predictive of later development of diabetic nephropathy, in Type 1 diabetic children aged ≥ 15 years.

Key words

Arterial blood pressure children glycosylated haemoglobin retinopathy Type 1 diabetes urinary albumin excretion 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • E. R. Mathiesen
    • 1
  • N. Saurbrey
    • 1
  • E. Hommel
    • 1
  • H. -H. Parving
    • 1
  1. 1.Hvidöre Hospital, Klampenborg, Department of PaediatricsGlostrup University HospitalGlostrupDenmark

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