Pediatric Nephrology

, Volume 8, Issue 6, pp 705–709 | Cite as

Haemolytic-uraemic syndrome in childhood: surveillance and case-control studies in Italy

  • Alessandra Gianviti
  • Francesco Rosmini
  • Alfredo Caprioli
  • Rosamaria Corona
  • Maria Chiara Matteucci
  • Flavia Principato
  • Ida Luzzi
  • Gianfranco Rizzoni
  • Italian HUS Study Group
Original Article


Seventy-six cases of haemolytic-uraemic syndrome (HUS) were collected over a 4-year period during a surveillance and case-control study. The annual incidence of 0.2 per 100,000 children aged 0–14 years is lower than in other countries; 34% had no prodromal diarrhoea. Evidence for verocytotoxin-producingEscherichia coli (VTEC) infection was found in 72% of patients and 3% of controls; 88% of patients with bloody diarrhoea, 67% with non-bloody diarrhoea and 55% without diarrhoea were VTEC positive. Seventy-three percent of patients had creatinine clearance ≥80 ml/min per 1.73 m2, normal blood pressure, no proteinuria and haematuria <2+ after 1 year of follow-up. One patient died and none had non-renal sequelae. VTEC positivity was significantly correlated with a good outcome, while the absence of diarrhoea and a high total white blood cell count at onset were not predictors of a bad outcome. Household contacts of HUS patients had diarrhoea more frequently than those of the control group, supporting the hypothesis of person-to-person transmission of VTEC infection.

Key words

Haemolytic-uraemic syndrome Surveillance study Case-control study Verocytotoxin-producingEscherichia coli infection 


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Copyright information

© IPNA 1994

Authors and Affiliations

  • Alessandra Gianviti
    • 1
  • Francesco Rosmini
    • 2
  • Alfredo Caprioli
    • 3
  • Rosamaria Corona
    • 2
  • Maria Chiara Matteucci
    • 1
  • Flavia Principato
    • 1
  • Ida Luzzi
    • 4
  • Gianfranco Rizzoni
    • 1
  • Italian HUS Study Group
  1. 1.Division of Nephrology and DialysisBambino Gesù Children's Research HospitalRomeItaly
  2. 2.Epidemiology and Biostatistic LaboratoryIstituto Superiore di SanitàRomeItaly
  3. 3.Ultrastructure LaboratoryIstituto Superiore di SanitàRomeItaly
  4. 4.Bacteriology and Mycology LaboratoryIstituto Superiore di SanitàRomeItaly

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