Experiments were performed on white mice with Ehrlich's ascitic carcinoma. 1∶20,000 adrenalin solution in a dose of 0.2 ml was repeatedly injected into the animals at different time intervals.
Under the effect of adrenalin a sharp depression of mitotic activity occurred in the corneal epithelium, and mitoses were absent almost completely. Conversely, a considerable increase in the number of cells, especially at the metaphase stage was noted in the carcinoma in these animals. The latter may evidently be explained by the diminished intensity of cellular reproduction as the result of a more prolonged period required for mitosis.
Obviously the cells of ascitic cancer were less sensitive to adrenalin than those of the corneal epithelium. While the latter completely lost their ability to multiply, cancer cells continued to divide — although at a slower rate—with the course of mitosis particularly delayed.
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Kozlov, V.V. The effect of adrenalin on the division of ascitic cancer cells and of normal epithelial cells. Bull Exp Biol Med 48, 1157–1163 (1959). https://doi.org/10.1007/BF00868921
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