Journal of Neurology

, Volume 242, Issue 9, pp 561–567

Propofol analgesia in central pain: Preliminary clinical observations

  • Sergio Canavero
  • Vincenzo Bonicalzi
  • Carlo Alberto Pagni
  • Giancarlo Castellano
  • Roberto Merante
  • Salvatore Gentile
  • Gianni Boris Bradac
  • Mauro Bergui
  • Paolo Benna
  • Sergio Vighetti
  • Mario Coletti Moia
Original Communication

DOI: 10.1007/BF00868808

Cite this article as:
Canavero, S., Bonicalzi, V., Pagni, C.A. et al. J Neurol (1995) 242: 561. doi:10.1007/BF00868808

Abstract

Propofol, an intravenous general anaesthetic, has been reported to relieve some forms of pruritus at subhypnotic doses. We assessed its effectiveness in 32 patients with several kinds of non-malignant chronic pain, in a placebo-controlled, double-blind study. We found that central pain, but not neuropathic pain, is at least partially controlled by propofol at subhypnotic doses, without major side-effects. In particular, allodynia associated with central, but no neuropathic, pain has been completely controlled. Propofol analgesia leads to renormalization of brain metabolism as seen on single photon emission computed tomography. We conclude that propofol may help in the diagnosis of central pain, particularly in unclear cases, and also in treatment. Possible mechanisms of action are discussed.

Key words

Central pain Neuropathic pain Propofol Single photon emission computed tomography 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Sergio Canavero
    • 1
    • 2
    • 8
  • Vincenzo Bonicalzi
    • 3
    • 2
  • Carlo Alberto Pagni
    • 1
    • 2
  • Giancarlo Castellano
    • 4
  • Roberto Merante
    • 4
  • Salvatore Gentile
    • 5
  • Gianni Boris Bradac
    • 7
  • Mauro Bergui
    • 7
  • Paolo Benna
    • 6
  • Sergio Vighetti
    • 6
  • Mario Coletti Moia
    • 6
  1. 1.Institute of Neurosurgery, Ospedale MolinetteUniversity of TurinTurinItaly
  2. 2.Service of NeuroanaesthesiologyOspedale Molinette, University of TurinTurinItaly
  3. 3.Neurosurgical Pain Relief Unit, Ospedale MolinetteUniversity of TurinTurinItaly
  4. 4.Service of Nuclear MedicineOspedale Molinette, University of TurinTurinItaly
  5. 5.Division of NeurologyOspedale S.G. BoscoTurinItaly
  6. 6.Service of Clinical NeurophysiologyOspedale Molinette, University of TurinTurinItaly
  7. 7.Department of NeuroradiologyOspedale Molinette, University of TurinTurinItaly
  8. 8.TurinItaly

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