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Pediatric Nephrology

, Volume 9, Issue 6, pp 694–699 | Cite as

Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

  • Diana Karpman
  • Annika Andreasson
  • Hans Thysell
  • Bernard S. Kaplan
  • Catharina Svanborg
Original Article

Abstract

Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-α (TNF-α) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-α were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-α were not detected in the serum (n=25) and urine (n=15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.

Key words

Interleukin-6 Tumor necrosis factor-α Hemolytic uremic syndrome Thrombotic thrombocytopenic purpura 

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Copyright information

© IPNA 1995

Authors and Affiliations

  • Diana Karpman
    • 1
  • Annika Andreasson
    • 2
  • Hans Thysell
    • 3
  • Bernard S. Kaplan
    • 4
  • Catharina Svanborg
    • 2
  1. 1.Department of PediatricsLund UniversityLundSweden
  2. 2.Department of Clinical ImmunologyLund UniversityLundSweden
  3. 3.Department of NephrologyLund UniversityLundSweden
  4. 4.Division of NephrologyUniversity of Pennsylvania, The Children's Hospital of PhiladelphiaPhiladelphiaUSA

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