Influence of prolonged physical exercise on the erythropoietin concentration in blood

  • H. -J. Schwandt
  • B. Heyduck
  • H. -C. Gunga
  • L. Röcker


Erythropoietin (EPO) and red blood cells were studied in 15 well-trained men before and several times after a marathon run. Changes in red blood cells reflected changes of plasma volume. Immediately after the run, red blood cells were increased due to haemoconcentration, whereas 31 h later the values were decreased due to haemodilution. The EPO concentration was increased 3 h, and more impressive 31 h, after the run. This long-lasting increase in EPO concentration after the marathon run would seem to be responsible for the increased red blood cell mass in long distance runners.

Key words

Erythropoietin Red blood cells Marathon running 


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  1. Berglund BO, Birgegård G, Hemmingsson P (1988) Serum erythropoietin in cross-country skiers. Med Sci Sports Exerc 20:208–209PubMedGoogle Scholar
  2. Beru N, McDonald J, Lacombe C, Goldwasser E (1986) Expression of the erythropoietin gene. Mol Cell Biol 6:2571–2575PubMedGoogle Scholar
  3. Brotherhood J, Brozovic B, Pugh LGC (1975) Haematological status of middle- and long-distance runners. Clin Sci Mol Med 48:139–145PubMedGoogle Scholar
  4. Casoni I, Borsetto C, Cavicchi A, Martinelli S, Conconi F (1985) Reduced hemoglobin concentration and red cell hemoglobinization in Italian marathon and ultramarathon runners. Int J Sports Med 6:176–179PubMedGoogle Scholar
  5. Castenfors J (1977) Renal function during prolonged exercise. Ann NY Acad Sci 301:151–159PubMedGoogle Scholar
  6. Davidson RJL, Robertson JD, Galea G, Maughan RJ (1987) Hematological changes associated with marathon running. Int J Sports Med 8:19–25PubMedGoogle Scholar
  7. De Paoli Vitali E, Guglielmini C, Casoni I, Vedovato M, Gilli P, Farinelli A, Salvatorelli G, Conconi F (1988) Serum erythropoietin in cross-country skiers. Int J Sports Med 9:99–101PubMedGoogle Scholar
  8. Dickson DN, Wilkinson RL, Noakes TD (1982) Effects of ultramarathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med 3:111–117PubMedGoogle Scholar
  9. Fried W, Johnson C, Heller P (1970) Observations on regulation of erythropoiesis during prolonged periods of hypoxia. Blood 36:607–616PubMedGoogle Scholar
  10. Gibson JG 2nd, Evans WA Jr (1937) Clinical studies of the blood volume. II. The relation of plasma and total blood volume to venous pressure, blood velocity rate, physical measurements, age and sex in ninety normal humans. J Clin Invest 16:317–328Google Scholar
  11. Gregersen MI, Rawson RA (1959) Blood volume. Physiol Rev 39:307–342PubMedGoogle Scholar
  12. Guglielmini C, Casoni I, Patracchini M, Manfredini F, Grazzi G, Ferrari M, Canconi F (1989) Reduction of Hb levels during the racing season in nonsideropenic professional cyclists. Int J Sports Med 10:352–356PubMedGoogle Scholar
  13. Jelkmann W (1986) Renal erythropoietin: properties and production. Rev Physiol Biochem Pharmacol 104:139–215PubMedGoogle Scholar
  14. Kjellberg SR, Rudhe U, Sjöstrand T (1950) Increase of the amount of hemoglobin and blood volume in connection with physical training. Acta Physiol Scand 19:146–151Google Scholar
  15. Lemke C, Müller A (1989) Erythropoietin — Ein Überblick. Folia Haematol 116:715–721Google Scholar
  16. Lijnen P, Hespel P, Fagard R, Lysens R, Vanden Eynde E, Goris M, Goossens W, Lissens W, Amery A (1988) Indicators of cell breakdown in plasma of men during and after a marathon race. Int J Sports Med 9:108–113PubMedGoogle Scholar
  17. Londoree BR, Allaire T (1969) Reticulocyte counts before and after exercise: trained vs. sedentary. Int Z Angew Physiol 27:226–229PubMedGoogle Scholar
  18. Migliaccio G, Migliaccio AR, Visser WM (1988) Synergism between erythropoietin and interleukin-3 in the induction of hematopoietic stem cell proliferation and erythroid burst colony formation. Blood 72:944–951PubMedGoogle Scholar
  19. Refsum HE, Jordfald G, Stromme SB (1976) Hematological changes following prolonged heavy exercise. Medicine sport, vol. 9. Advances in exercise physiology. Karger, Basle, pp 91–99Google Scholar
  20. Reinhart WH, Stäubli M, Straub PW (1983) Impaired red cell filterability with elimination of old red blood cells during a 100km race. J Appl Physiol 54:827–830PubMedGoogle Scholar
  21. Richalet JP, Boffa G, Antezana AM, Quintela A, Antezana G (1991) Effects of acute and chronic hypoxia on human erythropoietin control at rest and exercise. Abstracts of 7th International Hypoxia Symposium, February 26 to March 2, Chateau Lake Louise, Lake Louise, Alberta, CanadaGoogle Scholar
  22. Robertson JD, Maughan RJ, Davidson RJL (1988) Changes in red cell density and related indices in response to distance running. Eur J Appl Physiol 57:264–269Google Scholar
  23. Röcker L (1977) Der EinfluB körperlicher Aktivität auf das Blut, vol. 2. In: Hollmann W (ed) Zentrale Themen der Sportmedizin. Springer, Berlin Heidelberg New York, pp 91–111Google Scholar
  24. Röcker L, Neubauer H-D (1989) Veränderungen des roten Blutbildes nach einem Marathonlauf unter besonderer Berücksichtigung von Transferrin und Ferritin. In: Böning D, Braumann KM, Busse MW, Maassen N, Schmidt W (eds) Sport - Rettung oder Risiko für die Gesundheit? 31. Deutscher Sportärz-tekongreß Hannover 1988, Deutscher Arzte, Cologne, pp 108–110Google Scholar
  25. Röcker L, Kirsch KA, Stoboy H (1976) Plasma volume, albumin and globulin concentrations and their intravascular masses. A comparative study in endurance athletes and sedentary subjects. Eur J Appl Physiol 36:57–64Google Scholar
  26. Röcker L, Laniado M, Kirsch K (1983) The effect of physical exercise on plasma volume and red blood cell mass. In: Dunn CDR (ed) Current concepts in erythropoiesis. Wiley, Chichester, pp 245–277Google Scholar
  27. Sachs L (1974) Angewandte Statistik, Planung und Auswertung, Methoden und Modell, 4th edn. Springer, Berlin Heidelberg New YorkGoogle Scholar
  28. Saltin B, Blomqvist G, Mitchell JH, Johnson RL Jr, Wildenthal K, Chapman CB (1968) Response to exercise after bed rest and after training. A longitudinal study of adaptive changes in oxygen transport and body composition. Circulation 38 [Suppl 7]:1–78Google Scholar
  29. Schmidt W, Maassen N, Trost F, Böning D (1988) Training induced effects on blood volume, erythrocyte turnover and haemoglobin oxygen binding properties. Eur J Appl Physiol 57:490–498Google Scholar
  30. Schmidt W, Maassen N, Tegtbur U, Braumann KM (1989) Plasmavolumenveranderungen und Erythropoese nach einem Marathonlauf. In: Böning D, Busse KM, Maassen N, Schmidt W (eds) Sport - Rettung oder Risiko für die Gesundheit? 31. Deutscher Sportärztekongreß Hannover 1988, Deutscher Arzte, Cologne, pp 99–102Google Scholar
  31. Schooley JC, Mahlmann LJ (1975) Hypoxia and the initiation of erythropoietin production. Blood Cells 1:429–444Google Scholar
  32. Schuster SJ, Badiras EV, Costa-Giomi P, Weinmann R, Erslev AJ, Caro J (1989) Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Blood 73:13–16PubMedGoogle Scholar
  33. Schwandt H-J, Heyduck B, Röcker L (1990) Der Einfluß einer Ausdauerleistung auf das rote Blutbild und die Erythropoietin-Konzentration im Serum. 32. Deutscher Sportärztekon-greß München, 18.-21. Oktober 1990Google Scholar
  34. Söstrand T (1953) Volume and distribution of blood and their significance in regulating the circulation. Physiol Rev 33:202–228PubMedGoogle Scholar
  35. Stäubli M, Roessler B (1986) The mean red cell volume in long distance runners. Eur J Appl Physiol 55:49–53Google Scholar
  36. Strauss MB, Davis RK, Rosenbaum JD, Rossmeisl EC (1951) Water diuresis produced during recumbency by the intravenous infusion of isotonic saline solution. J Clin Invest 30:862–868PubMedGoogle Scholar
  37. Yoshimura H, Inoue T, Yamada T, Shiraki K (1980) Anemia during hard physical training (sports anemia) and its causal mechanism with special reference to protein nutrition. World Rev Nutr Diet 35:1–86PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • H. -J. Schwandt
    • 1
  • B. Heyduck
    • 1
    • 2
  • H. -C. Gunga
    • 2
  • L. Röcker
    • 1
    • 2
  1. 1.Institut für LeistungsmedizinAbteilung Sportphysiologie, BerlinBerlin 33Germany
  2. 2.Physiologisches Institut der Freien Universität BerlinBerlin 33Germany

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