Journal of Neurology

, Volume 239, Issue 6, pp 343–344

Familial CNS tumors

  • Jörn P. Sieb
  • Stefan-M. Putst
  • Anke Buch
Original Communications

DOI: 10.1007/BF00867592

Cite this article as:
Sieb, J.P., Putst, SM. & Buch, A. J Neurol (1992) 239: 343. doi:10.1007/BF00867592


A family with central nervous system tumors in five individuals in two generations is reported. Of five sisters, two had an isolated meningioma and one an epen dymoma. Amongst the four children of those affected there was a son with two cerebral meningiomas and a daugther with a spinal meningioma. Signs typical of von Recklinghausen neurofibromatosis (NF1) or bilateral acoustic neurofibromatosis (NF2) were not present. The pattern is consistent with autosomal dominant inheritance with relatively high penetrance.

Key words

Familial meningioma Familial ependymoma Neurofibromatosis 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Jörn P. Sieb
    • 1
  • Stefan-M. Putst
    • 2
  • Anke Buch
    • 1
  1. 1.Neurologische UniversitätsklinikBonn 1Germany
  2. 2.Division of Neurology, Cedars-Sinai Medical CenterUniversity of CaliforniaLos AngelesUSA
  3. 3.Neuromuscular Research Laboratory, Department of NeurologyMayo ClinicRochesterUSA

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