Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study
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A neurological surveillance was combined with prospective recording of upper respiratory and gastrointestinal infections and serological diagnosis of five common viral infections in 60 benign multiple sclerosis patients, with a mean follow-up of 31 months. During 4-week at risk (AR) periods encompassing common infections, a significant excess of MS relapses was found in the AR period, with a relative risk of 1.3. A seasonal variation of the MS relapse rate was found with a minimum in summer. There was a significant correlation between the number of AR relapses and the number of common infections per month explaining the periannual distribution of relapses. The non-AR relapses showed no seasonal variation. There was a significant correlation between adenovirus CF titre rises associated with upper respiratory infections and the occurrence of a major MS relapse in the AR period (n = 7), while influenza infections were not followed by a major MS relapse (n = 6). Linear homologies have been demonstrated between adenovirus and basic myelin protein. The epidemiological approach is essential to our understanding of systemic antigens triggering multiple sclerosis activity.
Key wordsMultiple sclerosis Viral infection Epidemiology Adenovirus
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- 2.Andersen O (1980) Restricted dissemination of clinically defined attacks in an MS incidence material. Acta Neurol Scand 62 [Suppl 77] 18Google Scholar
- 12.Kurtzke JF (1970) Clinical manifestations of multiple sclerosis. In: Vinken PJ, Bruyn GW (ed) Handbook of clinical neurology, vol 9. North-Holland, Amsterdam, p 161Google Scholar
- 14.Mårtensson E, Axelsson R, Oden A (1980) Prophylactic effect of continuous treatment with antidepressants. Curr Ther Res 28:767–776Google Scholar
- 15.Merck C, Angervall L, Kindblom LG, Odén A (1983) Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic-histiocytic origin. A clinicopathological and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand [Suppl] 282:1–40Google Scholar
- 17.Panitch HS, Bever T, Katz E, Johnson KP (1991) Upper respiratory tract infections trigger attacks of multiple sclerosis in patients treated with interferon. J Neuroimmunol [Suppl 1]:125Google Scholar
- 24.Sibley WA, Foley J (1965) Seasonal variation in multiple sclerosis and retrobulbar neuritis in Northeastern Ohio. Trans Am Neurol Assoc 90:295–297Google Scholar