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Journal of Neurology

, Volume 242, Issue 10, pp 683–688 | Cite as

Distribution of epidermal growth factor receptor gene amplification in brain tumours and correlation to prognosis

  • Uwe Diedrich
  • Jens Lucius
  • Eleonore Baron
  • Julianne Behnke
  • Brigitte Pabst
  • Barbara Zoll
  • U. Diedrich
Original Communication

Abstract

In 75 gliomas and 31 meningiomas, mutations at the epidermal growth factor receptor (EGFR) gene locus were restricted to gliomas. The ligands of this receptor, epidermal growth factor and transforming growth factor alpha, lacked quantitative changes at their loci in gliomas and meningiomas. EGFR gene amplification occurred in astrocytomas, oligodendrogliomas, ependymomas and glioblastomas. The frequency of this mutation significantly increased with the malignancy grade and the patient's age. Especially in glioblastomas of individuals aged over 64 years, EGFR gene mutations were observed without chromosome-10-specific allele losses. This finding contradicts the hypothesis that deletion of one entire chromosome 10 regularly precedes EGFR gene amplification in primary glioblastomas of patients aged over 50 years. It was found that most individuals whose gliomas carry an EGFR gene mutation have a poor prognosis, comparable to that of glioblastoma patients even when the tumour is graded as benign.

Keywords

EGFR gene amplification and expression Brain tumours Biological factors Prognosis 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Uwe Diedrich
    • 1
  • Jens Lucius
    • 2
  • Eleonore Baron
    • 2
  • Julianne Behnke
    • 2
  • Brigitte Pabst
    • 2
  • Barbara Zoll
    • 2
  • U. Diedrich
    • 3
  1. 1.Neurologische UniversitätsklinikGöttingenGermany
  2. 2.Institut für Humangenetik der UniversitätGöttingenGermany
  3. 3.Neurochirurgische UniversitätsklinikGöttingenGermany

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