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IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report

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Abstract

A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.

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Correspondence to Masaaki Morino.

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Morino, M., Inami, K., Shibuya, A. et al. IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report. Pediatr Nephrol 8, 345–346 (1994). https://doi.org/10.1007/BF00866358

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Key words

  • Splenectomy
  • IgA nephropathy
  • Immune complexes
  • Idiopathic thrombocytopenic purpura
  • Reticuloendothelial system