A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.
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Morino, M., Inami, K., Shibuya, A. et al. IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report. Pediatr Nephrol 8, 345–346 (1994). https://doi.org/10.1007/BF00866358
- IgA nephropathy
- Immune complexes
- Idiopathic thrombocytopenic purpura
- Reticuloendothelial system