Pediatric Nephrology

, Volume 8, Issue 3, pp 343–344 | Cite as

Clinical observations on the use of the Chinese herbTripterygium wilfordii Hook for the treatment of nephrotic syndrome

  • Xinyou Jiang
Brief Report


A preparation of extracts from the root of the Chinese medicinal herbTripterygium wilfordii Hook was administered orally at a dose of 1 mg/kg body weight per day to 13 children with idiopathic nephrotic syndrome. Eight children, including 4 who were steroid resistant, went into remission which was maintained in 4 for up to 3 years after withdrawal of treatment. In 3 children the proteinuria lessened with the return of plasma protein concentration to normal, and in 1 child this improvement was maintained for 4 years after treatment ceased. No serious side-effects were noted, but a temporary anti-fertility activity has been noted in other studies of both men and women.

Key words

Chinese herbs Tripterygium wilfordii Hook Nephrotic syndrome 


  1. 1.
    Zhang Xiao-qun, Zhang Zhao-he (1989) The immunosuppressive actions ofTripterygium wilfordii hook (a review). Shanghai J Immunol 9: 314–316Google Scholar
  2. 2.
    Lu Xie-yu, Ma Peng-cheng, Chen yun, Zhang Chong-pu, Zhang Yong-gang, Zhang Zheng-xing, Sheng Long-sheng, Li Shi-zhuang, An Deng-kui, He Cun-heng, Zheng Qi-tai (1990) The isolation and structure of tripchlorolide (T4) fromTripterygium wilfordii. Acta Acad Med Sin 12: 157–161Google Scholar

Copyright information

© IPNA 1994

Authors and Affiliations

  • Xinyou Jiang
    • 1
  1. 1.Center of Pediatric NephrologyNanjing Medical UniversityNanjingPeople's Republic of China

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