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Pediatric Nephrology

, Volume 8, Issue 2, pp 169–171 | Cite as

Possible pathogenic role of IgE in Henoch-Schönlein purpura

  • J. -C. Davin
  • G. Pierard
  • C. Dechenne
  • D. Grossman
  • J. Nagy
  • M. Quacoe
  • M. Malaise
  • M. Hall
  • F. Jansen
  • J. M. Chantraine
  • P. R. Mahieu
Original Article

Abstract

The incidences of clinical and biological markers of atopy were investigated in 16 children with IgA nephropathy (IgAN) (group A) and in 22 with Henoch-Schönlein purpura nephritis (HSPN) (group B). The incidence of increased plasma IgE levels according to age-matched normal values was significantly higher in group B (17/22, 77%) than in group A (7/16, 44%) (P<0.05). Although not significant, the incidences of positive RAST tests and of a history of typical atopic symptoms were also higher in group B [10/22 (45%) and 11/22 (50%), respectively] than in group A [4/16 (25%) and 5/16 (31%), respectively]. Moreover, IgE deposits were demonstrated by a peroxidase/anti-peroxidase method on cutaneous Langerhans and mast cells in 4 of 6 patients with HSPN. Thus immunoallergy might account, in some cases, for the cutaneous, intestinal and pulmonary signs observed in HSPN, but not in IgAN. We postulate stimulation of IgE-sensitized mast cells by specific antigens in the presence of IgA circulating immune complexes (CIC), release of vasoactive substances, increased capillary permeability and perivascular deposition of IgA CIC.

Key words

Atopy IgA nephropathy Henoch-Schönlein purpura IgE 

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Copyright information

© IPNA 1994

Authors and Affiliations

  • J. -C. Davin
    • 1
    • 4
  • G. Pierard
    • 2
    • 4
  • C. Dechenne
    • 1
    • 4
  • D. Grossman
    • 1
    • 4
  • J. Nagy
    • 3
    • 4
  • M. Quacoe
    • 1
    • 4
  • M. Malaise
    • 1
    • 4
  • M. Hall
    • 3
    • 4
  • F. Jansen
    • 3
    • 4
  • J. M. Chantraine
    • 1
    • 4
  • P. R. Mahieu
    • 1
    • 4
  1. 1.Paediatric Nephrology Unit and Department of Immunology/TransplantationState University of LiègeBelgium
  2. 2.Department of DermatopathologyState University of LiègeBelgium
  3. 3.Department of PathologyUniversity of PèczHungar
  4. 4.Paediatric Nephrology UnitUniversity of BrusselsBelgium

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