Preparation of brassylic acid from 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)-2,4-dione obtained by the condensation of cyclododecanone and urea or biuret

  • L. I. Zakharkin
  • I. M. Churilova
  • V. V. Guseva
Brief Communications


A simple method is proposed for the preparation of brassylic acid by the alkaline hydrolysis of 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)dione-2,4, which is the product of the condensation of cyclododecanone with urea or biuret. The condensation of the cyclododecanone with thiourea proceeds differently, leading to 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)spirocyclododecane-2-thione-4.


brassylic acid cyclododecanone 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)dione-2,4 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidinespirocyclododecane-2-thione-4 et meurea biuret methoxycarbonylcyclododecanone phenylamide of cyclododecanonecarboxylic acid 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • L. I. Zakharkin
  • I. M. Churilova
  • V. V. Guseva

There are no affiliations available

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