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On the reaction of certain 1,4-dihydropyridines with maleic anhydride and maleic acid

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  1. 1.

    The reaction with maleic anhydride cannot be used to determine the position of the double bonds in the dihydropyridine ring.

  2. 2.

    The direction of the reactions with dihydropyridines can be changed by steric hindrances in the dihydropyridine ring.

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Literature cited

  1. 1.

    K. Wallenfels and H. Schüly, Liebigs Ann. Chem.621, 86 (1959).

  2. 2.

    B. E. Norcross, P. E. Klinedinst, and F. H. Westheimer, J. Amer. Chem. Soc.82, 797 (1962).

  3. 3.

    D. C. Dittmer and J. M. Kolyer, J. Organ. Chem.27, 56 (1962).

  4. 4.

    E. A. Braude, J. Hannach, and R. Linstead, J. Chem. Soc. 3257 (1960).

  5. 5.

    A. F. E Sims and P. W. G. Smith, Proc. Chem. Soc. 282 (1958).

  6. 6.

    O. Mumm and O. Diederichsen, Liebigs Ann. Chem.538, 195 (1939).

  7. 7.

    K. Schenker and F. Druey, Helv. Chim. acta42, 1971 (1959).

  8. 8.

    P. Karrer, G. Schwarzenbach. and G. E. Utzinger, Helv. chim. acta20, 72 (1937).

  9. 9.

    O. M. Grishin and A. A. Yasnikov, Ukr. Khim. Zh.,28, 707 (1962).

  10. 10.

    D. Craig, A. K. Kuder, and J. Efroymson, J. Amer. Chem. Soc.72, 5236 (1950).

  11. 11.

    E. M. Kosower and T. S. Sorensen, J. Organ. Chem.27, 3764 (1962).

  12. 12.

    D. Mauzerall and F. H. Westheimer, J Amer. Chem. Soc.77, 2261 (1955).

  13. 13.

    R. F. Hutton and F. H. Westheimer, Tetrahedron3, 73 (1962).

  14. 14.

    K. Wallenfels and H. Schüly, Angew. Chem.69, 505 (1957).

  15. 15.

    K. C. Brannock, A. Bell, R. Burpitt, and C. A. Kelley, J. Organ. Chem.26, 625 (1961).

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Additional information

A. Kh. Pochikyan took part in the experimental portion of the work. The authors would like to express their gratitude to A. E Shilov and A. A. Yasnikov for their participation in the discussion of the results.

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 7, pp. 1322–1324, July, 1964

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Astakhova, A.S., Khidekel', M.L. On the reaction of certain 1,4-dihydropyridines with maleic anhydride and maleic acid. Russ Chem Bull 13, 1228–1230 (1964).

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  • Double Bond
  • Anhydride
  • Steric Hindrance
  • Maleic Acid
  • Dihydropyridine