Pediatric Nephrology

, Volume 9, Issue 2, pp 159–162

Mineral excretion following furosemide compared with bumetanide therapy in premature infants

  • Seetha Shankaran
  • Keh-chyang Liang
  • Nestor Ilagan
  • Larry Fleischmann
Original Article

DOI: 10.1007/BF00860731

Cite this article as:
Shankaran, S., Liang, K., Ilagan, N. et al. Pediatr Nephrol (1995) 9: 159. doi:10.1007/BF00860731

Abstract

Mineral excretion following single doses of furosemide were compared with bumetanide in a random cross-over trial in 17 premature infants. The mean birth-weight and gestational age were 889±85 g and 27±2 weeks. Following furosemide therapy, significantly higher chloride losses and urine volumes were noted in the first 8-h period compared with the second or third 8-h periods. Following bumetanide therapy, sodium, calcium, and chloride losses and urine volumes were significantly higher in the first 8 h compared with the second or third 8-h periods. Hourly sodium and chloride losses were significantly lower following bumetanide than furosemide during the first two 8-h periods. During the final 8-h period sodium, potassium, chloride, and calcium losses were significantly lower following bumetanide than following furosemide. Sodium loss per urine volume was lower with bumetanide than furosemide but calcium loss tended to be higher. Hence, bumetanide does not appear to be a calciumsparing diuretic following single-dose therapy.

Key words

Mineral excretion Bumetanide Furosemide Premature infants 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© IPNA 1995

Authors and Affiliations

  • Seetha Shankaran
    • 2
    • 3
    • 1
  • Keh-chyang Liang
    • 3
    • 1
  • Nestor Ilagan
    • 3
    • 1
  • Larry Fleischmann
    • 2
    • 1
  1. 1.Department of PediatricsWayne State University School of MedicineDetroitUSA
  2. 2.Children's Hospital of MichiganDetroitUSA
  3. 3.Grace HospitalDetroitUSA

Personalised recommendations