Pediatric Nephrology

, Volume 3, Issue 1, pp 37–42

Renal cystic disease of infancy: results of histochemical studies

A report of the Southwest Pediatric Nephrology Study Group
  • Regina Verani
  • Patrick Walker
  • Fred G. Silva
  • R. J. Hogg
Original Article

DOI: 10.1007/BF00859623

Cite this article as:
Verani, R., Walker, P., Silva, F.G. et al. Pediatr Nephrol (1989) 3: 37. doi:10.1007/BF00859623

Abstract

Histochemical techniques utilizingTetragonolobus lotus (proximal tubules),Arachis hypogaea (distal nephron, i.e., distal convoluted tubules and collecting ducts), and antibodies against Tamm-Horsfall protein (thick ascending limbs of Henle) were used to determine the site of origin of renal cysts in five children with autosomal recessive polycystic kidney disease (ARPKD) and three patients with glomerulocystic disease (GCD) presenting in the 1st year of life. The findings support a distal nephron origin for the cysts in the children who had ARPKD, whereas the majority of cysts in the children with GCD were confirmed as having a glomerular origin. Tamm-Horsfall protein was identified in the cysts of both ARPKD and GCD; this finding suggests free communication between some of the cysts with the thick ascending limb of Henle. An unexpected finding was the frequent presence of cysts surrounded by muscle fibers. We suggest that these cysts are of collecting duct origin.

Key words

Renal cysts Infancy Histochemistry Renal tubules 

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Copyright information

© IPNA 1989

Authors and Affiliations

  • Regina Verani
  • Patrick Walker
  • Fred G. Silva
  • R. J. Hogg
    • 1
  1. 1.Department of PediatricsBaylor University Medical CenterDallasUSA

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