Several disorders of hypomagnesaemia of hetary renal origin are now recognised. The cases of two sisters from a consanguineous marriage with the syndrome of renal magnesium wasting, hypercalciuria and nephrocalcinosis are presented. Pathological examination of the heterozygous parental kidneys revealed mild focal interstitial fibrosis. This condition is a previously unreported cause of end-stage renal failure in chilhhood, and this report suggests that transplantation from heterozygous parental donors can be successfully undertaken without recurrence currence of the syndrome.
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Nicholson, J.C., Jones, C.L., Powell, H.R. et al. Familial hypomagnesaemia — hypercalciuria leading to end-stage renal failure. Pediatr Nephrol 9, 74–76 (1995). https://doi.org/10.1007/BF00858976
- End-stage renal failure
- Renal transplantation