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Haemolytic uraemic syndrome associated with faecal cytotoxin and verotoxin neutralizing antibodies

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Forty-nine patients with a diagnosis of idiopathic haemolytic uraemic syndrome (HUS) were investigated to determine evidence of infection by verotoxin-producingEscherichia coli (VTEC). Free faecal cytotoxin active on Vero cells (VT) was detected in 15 out of 49 patients (31%). Seroconversion or high titres of VT-neutralizing antibodies were detected in 11 out of 18 patients (61%). The results of the present study suggest an association between HUS and infection by VTEC.

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Correspondence to Luis E. Voyer.

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Novillo, A.A., Voyer, L.E., Cravioto, R. et al. Haemolytic uraemic syndrome associated with faecal cytotoxin and verotoxin neutralizing antibodies. Pediatr Nephrol 2, 288–290 (1988). https://doi.org/10.1007/BF00858679

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Key words

  • Haemolytic uraemic syndrome
  • Verotoxin
  • Antibodies