Pediatric Nephrology

, Volume 7, Issue 4, pp 392–395 | Cite as

Impact of tuberculosis in children with idiopathic nephrotic syndrome

  • Udai Kala
  • Lawrence S. Milner
  • David Jacobs
  • Peter D. Thomson
Original Article
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Abstract

Forty black South African children (mean age 4.7±2.6 years) with idiopathic nephrotic syndrome due to focal glomerulosclerosis (FSGS) were evaluated. Tuberculosis (TB) was found in 37.5% of children with FSGS (FSGS-TB) compared with 6% of a comparable group with minimal lesion nephrotic syndrome. No significant differences were found in the initial mean serum albumin, cholesterol, triglyceride and creatinine levels in FSGS-TB compared with children with glomerulosclerosis but without TB (FSGS-nonTB). The mean serum levels of C4, IgA and IgM were increased by 30%, 25% and 23%, respectively in children with FSGS-TB compared with FSGS-nonTB. Initial estimated creatinine clearance was similar in the two groups, but after a mean follow-up of 2.4 years, the mean estimated creatinine clearance of children with FSGS-TB was significantly reduced by 46% from the initial value, but remained stable in the FSGS-nonTB group. FSGS-TB children also had significantly increased requirements for renal replacement therapy compared with children with FSGS-nonTB. We conclude that TB infection is commonly associated with FSGS in black South African children; this may have deleterious effects on renal function.

Key words

Tuberculosis Focal glomerulosclerosis Renal impairment 
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Copyright information

© IPNA 1993

Authors and Affiliations

  • Udai Kala
    • 1
  • Lawrence S. Milner
    • 1
  • David Jacobs
    • 1
  • Peter D. Thomson
    • 1
  1. 1.Department of Paediatrics, Baragwanath and Johannesburg HospitalsUniversity of WitwatersrandJohannesburgSouth Africa

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