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Glomerulocystic disease: unilateral involvement of a horseshoe kidney and in trisomy 18


Two occurrences of glomerulocystic kidney disease (GCD) in children younger than 1 year are described. One child was 3 months old with trisomy 18; the other child was 6 months old with GCD localized to one side of a horseshoe kidney. Lectin and immunohistochemical studies in tissue from the second child suggested that the entire nephron may be affected in GCD. There may also be overlap of morphological features between GCD and early stages of autosomal dominant polycystic kidneys.

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Correspondence to Randall D. Craver.

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Craver, R.D., Ortenberg, J. & Baliga, R. Glomerulocystic disease: unilateral involvement of a horseshoe kidney and in trisomy 18. Pediatr Nephrol 7, 375–378 (1993).

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Key words

  • Glomerulocystic disease
  • Autosomal dominant polycystic kidney disease
  • Horseshoe kidney
  • Trisomy 18
  • Renal dysplasia