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Difference in blood flow volume of the common carotid artery between vascular and non-vascular dementia detected by colour duplex sonography

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Using colour duplex sonography, blood flow volume in the common carotid artery was measured in 72 demented patients and 28 normal controls. Thirty-five patients with a Hachmski's ischaemic score of 7 or above and marked ischaemic lesions on CT were assigned to the vascular dementia (VD) group. Thirty three patients with probable Alzheimer's disease according to the NINCDS-ADRDA criteria, 2 patients with Parkinson's disease, 1 patient with spinocerebellar degeneration, and 1 patient with Pick's disease were assigned to the non-vascular dementia (nonVD) group. The sum of blood flow volume in the bilateral common carotid arteries (CCA flow) in the nonVD group and in the VD group was lower than that in the control group. The CCA flow in the VD group was lower than that in the nonVD group. Comparison of patients matched for both age and the Hasegawa's dementia rating scale also revealed lower CCA flow in the VD group than in the nonVD group. Linear discriminant function analysis showed that nearly 90% of the demented patients were correctly diagnosed as having VD or as having nonVD. These results show the usefulness of colour duplex sonography in the differential diagnosis of patients with dementia.

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  1. 1.

    American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn, revised. APA, Washington, DC

  2. 2.

    Bennett DA, Wilson RS, Gilley DW, Fox JH (1990) Clinical diagnosis of Binswanger's disease. J Neurol Neurosurg Psychiatry 53:961–965

  3. 3.

    Foerstl H, Biedert S, Hewer W (1989) Multiinfarct and Alzheimer-type dementia investigated by transcranial Doppler sonography. Biol Psychiatry 26:590–594

  4. 4.

    Frackowiak RSJ, Pozzilli C, Legg NJ, Du Boulay GH, Marshall J, Lenzi GL, Jones T (1981) Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain 104:753–778

  5. 5.

    Furuta A, Ishii N, Nishihara Y, Horie A (1991) Medullary arteries in aging and dementia. Stroke 22:442–446

  6. 6.

    Gemmell HG, Sharp PIT, Besson JAO, Crawford JR, Ebmeier KP, Davidson J, Smith FW (1987) Differential diagnosis in dementia using the cerebral blood flow agent99mTc HM-PAO: a SPECT study. J Comput Assist Tomogr 11:398–402

  7. 7.

    Gustafson L, Risberg J (1979) Regional cerebral blood flow measurements by the 133 Xe inhalation technique in differential diagnosis of dementia. Acta Neurol Scand 60 [Suppl 72]:546–547

  8. 8.

    Hachinski VC, Iliff LD, Phil M, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, Ross Russell RW, Symon L (1975) Cerebral blood flow in dementia. Arch Neurol 32:632–637

  9. 9.

    Hasegawa K, Inoue K, Moriya K (1974) An investigation of dementia rating scale for the elderly (in Japanese). Clin Psychiatry 16:33–37

  10. 10.

    Laffey PA, Peyster RG, Nathan R, Haskin ME, McGinley JA (1984) Computed tomography and aging: results in anormal population. Neuroradiology 26:273–278

  11. 11.

    Matsumoto M, Sekimoto H, Goriya Y, Nakano T, Ikegami H, Matsumoto M, Tsuchiya H, Matsubara J, Shimizu T (1988) Relationship between carotid blood flow volume and degree of dementia in the elderly studied with a two-dimensional echographically guided ultrasonic Doppler flow volumeter: a pilot study. J Cardiovasc Ultrasonogr 7:315–320

  12. 12.

    McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939–944

  13. 13.

    Obara K, Kodaira K (1984) Noninvasive quantitative assessment of carotid and cerebral arteriosclerosis: by ultrasonic quantitative blood flow measurement system and its clinical application. Jikeikai Med J 31:93–111

  14. 14.

    O'Leary DH, Polak JF, Wolfson SK Jr, Bond MG, Bommer W, Sheth S, Psaty BM, Sharrett AR, Manolio TA, on behalf of the CHS Collaborative Research Group (1991) Use of sonography to evaluate carotid atherosclerosis in the elderly: the cardiovascular health study. Stroke 22:1155–1163

  15. 15.

    Uematsu S, Folstein MF (1985) Carotid blood flow measured by an ultrasonic volume flowmeter in carotid stenosis and patients with dementia. J Neurol Neurosurg Psychiatry 48:1230–1233

  16. 16.

    Uematsu S, Yang A, Preziosi TJ, Kouba R, Toung TJK (1983) Measurement of carotid blood flow in man and its clinical application. Stroke 14:256–266

  17. 17.

    Wada T, Kodaira K, Fujishiro K, Okamura T (1991) Correlation of common carotid flow volume measured by ultrasonic quantitative flowmeter with pathological findings. Stroke 22:319–323

  18. 18.

    Yamanouchi H, Tomonaga M, Yoshimura M, Toyokura Y (1988) Pathological study on cerebral arteries in progressive subcortical vascular encephalopathy of Binswanger's type (PSVE) (in Japanese with English abstract). Jpn J Stroke 10:404–411

  19. 19.

    Yamashita K, Kobayashi S, Yamaguchi S, Kitani M, Okeda K, Fujihara S, Shimode K, Tsunematsu T (1989) Correlation between carotid blood flow and brain atrophy in patients with multi-infarct dementia. Gerontology 35:192–197

  20. 20.

    Yoshimura S, Kodaira K, Fujishiro K, Furuhata H (1981) A newly developed non-invasive technique for quantitative measurement of blood flow: with special reference to the measurement of carotid arterial blood flow. Jikeikai Med J 28:241–256

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Correspondence to Tadashi Hamada.

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Hamada, T., Takita, M., Kawano, H. et al. Difference in blood flow volume of the common carotid artery between vascular and non-vascular dementia detected by colour duplex sonography. J Neurol 240, 191–194 (1993). https://doi.org/10.1007/BF00857527

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Key words

  • Colour duplex sonography
  • Common carotid artery
  • Dementia