Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Asymptomatic isolated microhaematuria: natural history of 136 children

  • 58 Accesses

  • 36 Citations


In a mass screening programme, 251 children with isolated microhaematuria were detected. Of these 251 children, 115 were excluded from the study because of microhaematuria, secondary to a specific cause. The remaining 136 children were diagnosed as having asymptomatic isolated microhaematuria (ASH). Of these 136 children, 23 had evidence of urinary abnormalities in their family members. Red blood cell casts were evident in 31 children at their initial visit or during the follow-up period. Ten children had one or more episodes of macrohaematuria during the study. Renal biopsy was performed in 19 children because of indications of glomerular discase, and 13 of these 19 children had mild to moderate glomerulonephritis. None of these 136 children developed hypertension or renal impairment after a mean period of 7.4 years (range 6–13 years). Thirty-five children had normal urinary findings within 6 years of their initial visit, and 100 have had persistent microhaematuria, without proteinuria throughout the follow-up period. The other child had microhaematuria with proteinuria greater than 1 g/m2 per day at the end of the study. This study suggests that the prognosis of ASH is good and that renal biopsy is not indicated for children with ASH.

This is a preview of subscription content, log in to check access.


  1. 1.

    Kitagawa T (1988) Lessons learned from the Japanese nephritis screening study. Pediatr Nephrol 2: 256–263

  2. 2.

    Hisano S, Ueda K (1989) Asymptomatic haematuria and proteinuria: renal pathology and clinical outcome in 54 children. Pediatr Nephrol 3:229–234

  3. 3.

    Vehaskari VM (1989) Asymptomatic heamturia—a cause for concern? Pediatr Nephrol 3:240–241

  4. 4.

    Dodge WF, West EF, smith EH, Bunce H III (1976) Proteinuria and hematuria in schoolchildren. J Pediatr 88:327–347

  5. 5.

    Vehaskari VM, Rapola J, Koskimies O, Savilahti E, Vilska J, Hallman N (1979) Microscopic hematuria in schoolchildren: epidemiology and clinicopathologic evaluation. J. Pediatr 95:676–684

  6. 6.

    Trachtman H, Weiss RA, Bennett B, Greifer I (1984) Isolated hematuria in children: indications for a renalbiopsy. Kidney Int 25:94–99

  7. 7.

    Miller PFW, Speirs NJ, Aparicio SR, Lendon M, Savage JM, Postlewaite RJ, Brocklebank JT, Houston IB, Meadow SR (1985) Long term prognosis of recurrent haematuria. Arch. Dis Child. 60:420–425

  8. 8.

    Túri S, Visy M, Vissy A, Jászai V, Czirbesz Z, Haszon Z, Szelid Z, Ferkis I (1989) Long-term follow-up, of patients with persistent/recurrent, isolated haematuria: a Hungarian multicentre study. Pediatr Nephrol 3:235–239

  9. 9.

    Stapleton FB, Roy S III, Noe HN, Jerkins GR (1984) Hypercalciuria in children with hematuria. N Engl J Med 310:1345–1348

  10. 10.

    Task Force on Blood Pressure Control in Children (1977) Report of the task force on blood pressure control in children. Pediatrics 59 [Suppl 5]:797–820

  11. 11.

    Sakaguchi H (1979) World Health Organization classification of glomerular disease. Jpn J Nephrol 21:349–355

  12. 12.

    Perlman LV, Herdman RC, Kleinman H, Vernier RL (1965) Poststreptococcal glomerulonephritis. A ten-year follow-up of an epidemic. JAMA 194:175–182

  13. 13.

    Kaplan EL, Anthony BF, Chapman SS, Wannamaker LW (1970) Epidemic acute glomerulonephritis associated with type 49 streptococcal pyoderma. I. Clinical and laboratory findings. Am J Med 48: 9–27

  14. 14.

    Vehaskari VM (1987) Symptomless hematuria in children. In: Murakami K, Kitagawa T, Yabuta K, Sakai T (eds) Recent advances in pediatric nephrology. Excerpta Medica, Amsterdam, pp 333–336

Download references

Author information

Correspondence to Satoshi Hisano.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hisano, S., Kwano, M., Hatae, K. et al. Asymptomatic isolated microhaematuria: natural history of 136 children. Pediatr Nephrol 5, 578–581 (1991). https://doi.org/10.1007/BF00856642

Download citation

Key words

  • Urine screening
  • Asymptomatic haematuria
  • Isolated haematuria