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Reaction of s-(β-alkylmercaptoethyl) diphenylthiophosphinates, O-(β-alkylmercaptoethyl) diphenylphosphinates and their methiodides with butyrylcholinesterase

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Conclusions

  1. 1.

    A study was made of the inhibiting activity of some S-(β-alkylmercaptoethyl) diphenylthiophosphinates, O-(β-alkylmercaptoethyl) diphenylphosphinates and their methiodides toward butyrylcholinesterase.

  2. 2.

    The studied compounds are inhibitors with a combined type of action, which increases with increase in the length of the alkyl radical that is attached to either the sulfide or the sulfonium sulfur atom.

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Literature cited

  1. 1.

    A. P. Brestkin, I. L. Brik, R. I. Volkova, N. N. Godovikov, Kh. Kh. Gurdaliev, M. I. Kabachnik, and N. A. Kardanov, Dokl. Akad. Nauk SSSR,200, 103 (1972).

  2. 2.

    N. N. Godovikov, N. A. Kardanov, and M. I. Kabachnik, Zh. Obshch. Khim.,42, 273 (1972).

  3. 3.

    A. P. Brestkin, R. I Volkova, N. N. Godovikov, and M. I Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim., 2020 (1968).

  4. 4.

    A. P. Brestkin, R. I. Volkova, and E. V. Rozengart, Dokl. Akad. Nauk SSSR,157, 1459 (1964).

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    R. I. Volkova, Biokhimiya,30, 292 (1965).

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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 622–627, March, 1973.

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Brestkin, A.P., Volkova, R.I., Godovikov, N.N. et al. Reaction of s-(β-alkylmercaptoethyl) diphenylthiophosphinates, O-(β-alkylmercaptoethyl) diphenylphosphinates and their methiodides with butyrylcholinesterase. Russ Chem Bull 22, 595–599 (1973). https://doi.org/10.1007/BF00854033

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Keywords

  • Sulfur
  • Sulfonium
  • Sulfide
  • Inhibiting Activity
  • Alkyl Radical