Pediatric Nephrology

, Volume 2, Issue 4, pp 415–418 | Cite as

Haemolytic uraemic syndrome and pseudomembranous colitis

  • N. Rooney
  • S. Variend
  • L. S. Taitz
Original Article


Two cases of haemolytic uraemic syndrome (HUS) associated with pseudomembranous colitis (PMC) are described. The toxin ofClostridium difficile was detected post mortem in the stool of one patient and the other patient showed a good therapeutic response to oral vancomycin, an antibiotic with established efficacy in the management of PMC. When associated with HUS, PMC is probably an independent specific disease that, in common with many other infections, may activate HUS.

Key words

Haemolytic uraemic syndrome Pseudomembranous colitis 


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  1. 1.
    Gasser VC, Gautier E, Stock A (1955) Hämolytisch-urämische syndrome. Schweiz Med Wochenschr 85:905Google Scholar
  2. 2.
    Whitington PF, Friedman AL, Chesney RW (1979) Gastrointestinal disease in the hemolytic uremic syndrome. Gastroenterology 76:728–733Google Scholar
  3. 3.
    Sunn CCJ, Hill JL, Coombs JW (1983) Hemolytic uremic syndrome: initial presentation mimicking intestinal intussusception. Pediatr Pathol 1:415–422Google Scholar
  4. 4.
    Case records of Massachusetts General Hospital (1981) Case 12. N. Engl J Med 304:715Google Scholar
  5. 5.
    Tochen ML, Campbell JR (1977) Colitis in children with haemolytic uraemic syndrome. J Pediatr Surg 12:213Google Scholar
  6. 6.
    Smith CD, Schuster SR, Gruppe WE, Vawter GF (1978) Hemolytic uremic syndrome: a diagnostic and therapeutic dilemma for the surgeon. J Pediatr Surg 13:597–604Google Scholar
  7. 7.
    Larson HE, Price AB, Honour P, Borriello SP (1978)Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet II:1063–1066Google Scholar
  8. 8.
    Chadarevian JP de, Kaplan BS (1978) The hemolytic uremic syndrome of childhood. Perspect Pediatr Pathol 4:465–502Google Scholar
  9. 9.
    Viscidi RD, Bartlett JG (1981) Antibiotic associated pseudomembranous colitis in children. Pediatrics 67:348–386Google Scholar
  10. 10.
    Buts JP, Weber AM, Roy CC, Morris CL (1977) Pseudomembranous enterocolitis in childhood. Gastroenterology 73:823–827Google Scholar
  11. 11.
    Welch DF, Marks MI (1984) IsClostridium difficile pathogenic in infants? J Pediatr 100:393–394Google Scholar
  12. 12.
    Price AB, Pseudomembranous colitis. In: Wright R (ed) Recent advances in gastrointestinal pathology. Saunders, PhiladelphiaGoogle Scholar
  13. 13.
    Karmali MA, Steele BT, Petric M, Lim C (1983) Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producingEscherichia coli in stools. Lancet I:619–620Google Scholar
  14. 14.
    Neill MA, Tarr PI, Clausen CR, Christie DL, Hickman RO (1987)Escherichia coli 0157: HT as the predominant pathogen associated with the hemolytic-uremic syndrome: a prospective study in the Pacific Northwest. Pediatrics 80:37–40Google Scholar
  15. 15.
    Baker NM, Mills AF, Rachman I (1974) Haemolytic uraemic syndrome in typhoid fever. Br Med J 2:84Google Scholar
  16. 16.
    Koster F, Levin J, Walker L (1978) Hemolytic uremic syndrome after shigellosis. Relation to endotoxaemia and circulating immune complexes. N Enngl J Med 298:927–933Google Scholar
  17. 17.
    Chesney R, Kaplan BS (1974) Hemolytic-uremic syndrome with shigellosis. J Pediatr 84:312–313Google Scholar

Copyright information

© IPNA 1988

Authors and Affiliations

  • N. Rooney
    • 1
  • S. Variend
    • 2
  • L. S. Taitz
    • 3
  1. 1.Department of PathologyBristol Royal InfirmaryBristolUK
  2. 2.Department of PathologyChildren's HospitalSheffieldUK
  3. 3.Department of PaediatricsChildren's HospitalSheffieldUK

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