Pediatric Nephrology

, Volume 7, Issue 5, pp 609–611

Cell death programmed in uninduced metanephric mesenchymal cells

  • Chizuko Koseki
Renal Organogenesis Original Article

DOI: 10.1007/BF00852566

Cite this article as:
Koseki, C. Pediatr Nephrol (1993) 7: 609. doi:10.1007/BF00852566


Metanephric mesenchyme may be converted to epithelia by the uteric bud (in vivo) and the spinal cord (in vitro). In their absence, the uninduced cells die or disappear. Morphological data, both in vitro and vivo, suggest that the demise of these cells is brought about by apoptosis, programmed cell death. By measuring DNA fragmentation in induced and uninduced cells, this study confirms not only that apoptosis occurs in the absence of an inducer, but also suggests that rescue from this process may be an important step in kidney development.

Key words

Apoptosis (programmed cell death) Metanephric mesenchyme DNA fragmentation Induction 

Copyright information

© IPNA 1993

Authors and Affiliations

  • Chizuko Koseki
    • 1
  1. 1.Department of Structure AnalysisNational Cardiovascular Centre, Research InstituteSuita, OsakaJapan

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