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Isotopic exchange of hydrogen in 3,5-dimethylisoxazole with acids

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Summary

The hydrogen atom on C4 of 3,5-dimethylisoxazole undergoes hydrogen isotope exchange in strongly acidic media. A study of the kinetics of this process also showed that the reactivity of the isoxazole ring to electrophilic substitution reactions decreases sharply in large excess of sulfuric acid.

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Translated from Izvestiya Akademii Nauk SSR, Seriya Khimicheskaya, No. 5, pp. 936–938, May, 1964

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Setkina, V.I., Sokolov, S.D. Isotopic exchange of hydrogen in 3,5-dimethylisoxazole with acids. Russ Chem Bull 13, 876–878 (1964). https://doi.org/10.1007/BF00846516

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Keywords

  • Hydrogen
  • Sulfuric Acid
  • Hydrogen Atom
  • Acidic Medium
  • Large Excess