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Effect of benactyzine and arecoline on the45Ca uptake by rat brain nerve endings

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The effect of the central cholinolytic benactyzine and the cholinomimetic arecoline on the uptake of45Ca by rat brain synaptosomes was studied in vitro. Benactyzine was shown to cause biphasic changes (a decrease followed by an increase) in the intensity of uptake of the isotope, whereas arecoline led to a rapid initial increase in45Ca uptake. Benactyzine was shown to depress the effect of arecoline and depolarization on uptake of the isotope. It is concluded that the increase in45Ca uptake through the action of arecoline is connected with activation of Nachannels. Benactyzine, on the other hand, reduces the permeability of the these channels for45Ca and activates the Ca-channels proper.

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Literature Cited

  1. 1.

    A. L. Bandman, L. V. Smirnova, and G. A. Sofronov, Byull. Éksp. Biol. Med., No. 7, 56 (1973).

  2. 2.

    I. I. Baryshnikov, Tr. Voen.-Med. Akad.,190, 138 (1970).

  3. 3.

    N. R. Elaev, M. O. Karryeva, and M. P. Podosinovikova, Farmakol. Tolsikol., No. 5, 632 (1972).

  4. 4.

    S. S. Krylov and E. A. Snegirev, Byull. Éksp. Biol. Med., No. 9, 49 (1970).

  5. 5.

    V. F. Shirokii, The Problem of Quality of Chemical Stimulation [in Russian], Volgograd (1950).

  6. 6.

    L. G. Abood, in: Psychotomimetic Drugs (ed. by D. H. Efron), New York (1970), p. 67.

  7. 7.

    P. E. Baker, A. L. Hodgkin, and E. B. Ridgway, J. Physiol. (London),218, 709 (1971).

  8. 8.

    T. Godfraind, in: Pharmacology and the Future of Man (International Congress), Vol. 4, Basel (1973), p. 344.

  9. 9.

    B. Katz and R. Miledi, J. Physiol. (London),203, 459 (1969).

  10. 10.

    W. Van der Kloot and H. Kita, J. Membrane Biol.,14, 365 (1973).

  11. 11.

    O. H. Lowry, N. J. Rosebrough, A. L. Farr, et al., J. Biol. Chem.,193, 265 (1951).

  12. 12.

    E. Matthews and J. Nordmann, Molec. Pharmacol.,12, 778 (1976).

  13. 13.

    E. Muscholl, H. Ritzel, and K. Rossler, Brit. J. Pharmacol.,55, 248 (1975).

  14. 14.

    H. Tischer and W. Oelssner, Acta Biol. Med. Germ.,18, 443 (1967).

  15. 15.

    W. Whittaker, Prog. Biophys. Molec. Biol.,15, 39 (1965).

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Semenov, E.V. Effect of benactyzine and arecoline on the45Ca uptake by rat brain nerve endings. Bull Exp Biol Med 86, 1168–1170 (1978).

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Key words

  • synaptosomes
  • benactyzine
  • arecoline
  • depolarization
  • 45Ca uptake