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Cancerolytic peptides with directed action

6. Bis-1-aziridinylphosphinyl derivatives of amines, amino acids, and peptides


  1. 1.

    Some new derivatives of amines, amino acids, and peptides containing bis-1-aziridinylphosphinyl groups were prepared.

  2. 2.

    Bis-1-aziridinylphosphinyl and bis-1-aziridinylphosphinothioyl groups can be introduced by the direct phosphorylation of amines and their derivatives with the aid of bis-1-aziridinylphosphinyl chloride and bis-1-aziridinylphosphinothioyl chloride.

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Literature cited

  1. 1.

    I. L. Knunyants, O. V. Kil'disheva, N. E. Golubeva, and S. Zurabyan, DAN SSSR,142, 370 (1962).

  2. 2.

    O. Friedman et al., J. Med. Chem.,6, 449 (1963).

  3. 3.

    Z. V. Popova and V. G. Nemets, Tr. Leningr. tekhn. inst.,40, 180 (1957).

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This article is published in accordance with a resolution of the Conference of Editors-in-Chief of Journals of the Academy of Sciences of the USSR of July 12, 1962, as a dissertation paper by S. É. Zurabyan.

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya No. 11, pp. 2036–2042, November, 1964

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Zurabyan, S.É., Keblas, S.S. & Knunyants, I.L. Cancerolytic peptides with directed action. Russ Chem Bull 13, 1932–1936 (1964).

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  • Peptide
  • Chloride
  • Directed Action
  • Direct Phosphorylation