Studies on the immediate and delayed leucocytosis elicited by brief (30-min) strenuous exercise
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Eight healthy male volunteers exercised for two 30-min sessions starting 3 h apart on an electronically braked cycle ergometer at a work load (mean 155.9 W, SD 33.4 W) which required an oxygen consumption that was 70% of their maximal rate of oxygen uptake. Venous blood samples were taken through an indwelling cannula over a period of 6 h beginning shortly before the first bout of exercise and were analysed for routine haematological parameters and for lactate, noradrenaline, adrenaline and cortisol. Both bouts of exercise induced an immediate leucocytosis due to rises in lymphocytes and neutrophils but only the first exercise bout induced a substantial delayed neutrophilia. In at least five subjects, changes in lymphocyte and platelet numbers were correlated (Spearman's rank procedure,P<0.05) with simultaneous changes in the plasma concentrations of lactate, noradrenaline and adrenaline over the 6-h period studied. Increases in the plasma concentration of cortisol due to exercise correlated positively with the percentage changes in neutrophil numbers at 3 h and 6 h. These results are consistent with the suggestion that the immediate and delayed leucocytosis induced by exercise are mediated respectively by catecholamine and by cortisol.
Key wordsLeucocytes Lymphopenia Granulocytosis Catecholamines Cortisol
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- Garrey WE, Bryan WR (1935) Variations in white blood cell counts. Physiol Rev 15:597–638Google Scholar
- Gimenez M, Mohan-Kumar T, Humbert JC, De Talance N, Buisine J (1986) Leukocyte, lymphocyte and platelet response to dynamic exercise; duration or intensity effect? Eur J Appl Physiol 55:465–470Google Scholar
- Hansen J-B, Wilsgard L, Osterud B (1991) Biphasic changes in leukocytes induced by strenuous exercise. Eur J Appl Physiol 62:157–161Google Scholar
- Masuhara M, Kami K, Umobayasi K, Tatsumi N (1987) Influences of exercise on leucocyte count and size. J Sports Med 27:285–290Google Scholar
- McCarthy DA, Perry JD, Melsom RD, Dale MM (1987) Leucocytosis induced by exercise. Br Med J 295:6Google Scholar
- Moorthy AV, Zimmerman SW (1978) Human leucocyte response to an endurance run. Eur J Appl Physiol 38:271–276Google Scholar
- Saltin B (1964) Aerobic work capacity and circulation at exercise in man. Acta Physiol Scand [Suppl] 230:1–52Google Scholar
- Schneider EC, Havens LC (1915) Changes in the blood after muscular activity and during training. Am J Physiol 36:239–259Google Scholar
- Törnquist L, Vartia P, Vartia YO (1985) How should relative changes be measured? Am Stat 39:43–46Google Scholar
- Wade AJ (1986) An exercise testing system designed for student use. J Physiol (Lond) 381:12 pGoogle Scholar