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European Journal of Nuclear Medicine

, Volume 16, Issue 4–6, pp 303–305 | Cite as

Detection of inflammatory lesions with radiolabelled immunoglobuline

  • D. Blok
  • M. v. Ogtrop
  • J. W. Arndt
  • J. A. J. Camps
  • R. I. J. Feitsma
  • W. Goedemans
  • E. K. J. Pauwels
Original article

Abstract

Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium.

Key words

Immunoglobulins Infection Inflammation 99mTc labelling 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • D. Blok
    • 1
    • 2
  • M. v. Ogtrop
    • 3
  • J. W. Arndt
    • 1
  • J. A. J. Camps
    • 1
  • R. I. J. Feitsma
    • 1
  • W. Goedemans
    • 4
  • E. K. J. Pauwels
    • 1
  1. 1.Departments of Diagnostic Radiology, Division of Nuclear MedicineUniversity Hospital Leiden2333AA LeidenThe Netherlands
  2. 2.Departments of Clinical Pharmacy and ToxicologyUniversity Hospital Leiden2333AA LeidenThe Netherlands
  3. 3.Departments of Infectious DiseasesUniversity Hospital Leiden2333AA LeidenThe Netherlands
  4. 4.Mallinckrodt Diagnostica Holland BV.ZG PettenThe Netherlands

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