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Biologically active glutamylpeptide found in rabbit bone marrow

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A biologically active glutamylpeptide with unusual rotation of the polarization plane, opposite to that observed for natural proteins, has been found in rabbit bone marrow and the technique of its isolation in a chromatographically pure form is described. In a concentration of 10−5 M the isolated peptide reduces the survival rate of Chinese hamster fibroblast-like cells in culture by 70% and in certain physicochemical properties it resembles the glutamylpeptide with cytogenetic activity and capable of potentiating the mutagenic action of ionizing radiation, previously isolated from plants.

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Laboratory of Molecular Radiobiology, Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino-on-Oka. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 12, pp. 84–86, December, 1975.

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Medvedev, A.I., Medvedeva, I.F., Nazarova, L.F. et al. Biologically active glutamylpeptide found in rabbit bone marrow. Bull Exp Biol Med 80, 1494–1496 (1975). https://doi.org/10.1007/BF00842649

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Key Words

  • bone marrow tissue
  • biologically active substances
  • peptides
  • mutagens