European Journal of Nuclear Medicine

, Volume 24, Issue 6, pp 670–673

Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography

  • Kazunari Ishii
  • Masahiro Sasaki
  • Shigeru Yamaji
  • Setsu Sakamoto
  • Hajime Kitagaki
  • Etsuro Mori
Short Communication

Abstract

Although decreased posterior cingulate metabolism in Alzheimer's disease (AD) has been previously reported, there have been no reports on posterior cingulate perfusion. In this study we evaluated posterior cingulate perfusion as a relative value using statistical parametric maps (SPMs) and as an absolute value using conventional region of interest (ROI) settings. Twenty-eight subjects, including 14 patients with mild AD (mean age: 66.4±12.1 years) and 14 normal controls (65.9±7.3 years) were studied. Regional Cerebral blood flow (CBF) was measured with H215O and positron emission tomography (PET). In the SPM analysis, the left posterior cingulate and left parietotemporal CBFs were significantly decreased in the patients with mild AD (P<0.001). At a louver statistical threshold (P<0.05), the right posterior cingulate and right parietotemporal CBFs were also significantly decreased in the AD patients. In the ROI studies, the left parietal and posterior cingulate CBFs in the patients with mild AD were significantly lower than those of the normal controls by analysis of variance and post-hoc Scheffé's test (P<0.001). We conclude that posterior cingulate perfusion is decreased in mild AD, reflecting the pathological changes and metabolic reduction in the posterior cingulate gyrus that have previously been reported to occur in mild AD.

Key words

Positron emission tomography Oxygen-15 labelled water Alzheimer's disease Cerebral blood flow posterior cingulate gyrus 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Kazunari Ishii
    • 1
  • Masahiro Sasaki
    • 1
  • Shigeru Yamaji
    • 1
  • Setsu Sakamoto
    • 1
    • 2
  • Hajime Kitagaki
    • 1
  • Etsuro Mori
    • 3
  1. 1.Division of Neuroimaging ResearchHyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD)HimejiJapan
  2. 2.Department of RadiologyKobe University School of MedicineKobeJapan
  3. 3.Division of Clinical NeurosciencesHyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD)HimejiJapan
  4. 4.Hyogo Institute for Aging Brain and Cognitive DisordersHyogoJapan

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