European Journal of Nuclear Medicine

, Volume 24, Issue 6, pp 615–620 | Cite as

Preliminary assessment of fluorine-18 fluorodeoxyglucose positron mission tomography in patients with bladder cancer

  • Shigeru Kosuda
  • Paul V. Kison
  • Robert Greenough
  • H. Barton Grossman
  • Richard L. Wahl
Original Article


The purpose of this study was to assess the feasibility of imaging of bladder cancer with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. We studied 12 patients with histologically proven bladder cancer who had undergone surgical procedures and/or radiotherapy. Retrograde irrigation of the urinary bladder with 1000–3710 ml saline was performed during nine of the studies. Dynamic and static PET images were obtained, and standardized uptake value images were reconstructed. FDG-PET scanning was true-positive in eight patients (66.7%), but false-negative in four (33.3%). Of 20 organs with tumor mass lesions confirmed pathologically or clinically, 16 (80%) were detected by FDG-PET scanning. FDG-PET scanning detected all of 17 distant metastatic lesions and two of three proven regional lymph node metastases. FDG-PET was also capable of differentiating viable recurrent bladder cancer from radiation-induced alterations in two patients. In conclusion, these preliminary data indicate the feasibility of FDG-PET imaging in patients with bladder cancer, although a major remaining pitfall is intense FDG accumulation in the urine.

Key words

Bladder cancer Fluorine-18 fluorodeoxyglucose Positron emission tomography 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Shigeru Kosuda
    • 1
  • Paul V. Kison
    • 1
  • Robert Greenough
    • 1
  • H. Barton Grossman
    • 2
  • Richard L. Wahl
    • 1
  1. 1.Department of Internal Medicine, Division of Nuclear MedicineThe University of Michigan Medical CenterAnn ArborUSA
  2. 2.Department of Urology and Cell BiologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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